Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes

Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes

SPG11 and SPG15 are two hereditary spastic paraplegia forms characterized by autophagosome accumulation, reduced free lysosomes and defects in autophagic lysosomal reformation (ALR). We demonstrated that attempts to rescue ALR and/or lysosome biogenesis are critical strategies for SPG15 phenotype an...

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Bibliographic Details
Main Authors: Chiara Vantaggiato, Giulia Guarato, Francesca Brivio, Elena Panzeri, Beatrice Speltoni, Sentiljana Gumeni, Genny Orso, Filippo Maria Santorelli, Maria Teresa Bassi
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Naringenin
Tideglusib
SMER28
ALR
Lysosomes
SPG15
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002610
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