Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting
Abstract Background Despite the interconnectedness of oral health and the cardiometabolic syndrome (CMS), the role of oral parameters in diagnosing and predicting CMS risk has been underexplored, particularly in African populations. This study aims to investigate the relationships between oral param...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-025-06481-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238232528584704 |
|---|---|
| author | Adeniyi Oluwadaisi Oluwadare Ogunlade Foluso Owotade Elijah Olufemi Oyetola Adetayo Aborisade Asafa Muritala Abiola |
| author_facet | Adeniyi Oluwadaisi Oluwadare Ogunlade Foluso Owotade Elijah Olufemi Oyetola Adetayo Aborisade Asafa Muritala Abiola |
| author_sort | Adeniyi Oluwadaisi |
| collection | DOAJ |
| description | Abstract Background Despite the interconnectedness of oral health and the cardiometabolic syndrome (CMS), the role of oral parameters in diagnosing and predicting CMS risk has been underexplored, particularly in African populations. This study aims to investigate the relationships between oral parameters and CMS risk as a noninvasive means of screening and diagnosis. Methods The study utilized an observational study design. Oral health parameters, anthropometry indices, blood pressure profiles and laboratory indicators of adults with CMS were compared with healthy controls. The relationships of the dental caries, periodontal index, neck circumference, salivary oxidative index of Ferric-Reducing Antioxidant Power (FRAP) and uric acid with variables related to cardiometabolic syndrome in the study group and controls were analyzed. Results Besides height of respondents, all anthropometric variables of weight, BMI, neck and waist circumference were significantly higher in the CMS group (p < 0.001). Saliva pH in CMS participants at 6.90 was significantly lower than the pH of the control group at 7.00 (p = 0.018) while the salivary uric acid level in the CMS group at 4.14 was significantly greater than in “Control” group at 3.06 (p = 0.018). The mean salivary FRAP was significantly greater in the saliva of CMS subjects than in controls (p < 0.001). Similarly, there were also significant differences between the median serum uric acid values(p = 0.002) and serum FRAP scores (p < 0.001). The mean Decayed, Missing and Filled Teeth (DMFT) value for CMS was significantly higher at 1.04 ± 1.13 than that of controls at (0.43 ± 0.73) (p < 0.001) while the Periodontal Inflamed Surface Area (PISA) were also significantly higher (p < 0.001) in CMS patients at 169.43 ± 91.71 mm2 compared to controls (62.28 ± 38.23 mm2). Regression analysis showed salivary, and serum FRAP had odds ratio of 2.39 and 5.39 respectively. Conclusion In this study, dental caries was significantly associated with cardiometabolic syndrome. Similarly, the periodontal inflamed surface area index was positively associated with the CMS compared with the control. Salivary and serum oxidative stress (uric acid and FRAP) values were significantly related in patients with CMS compared with controls. The study concluded that oral health parameters and anthropometric parameters can be excellent noninvasive tools for assessing cardiometabolic risk in community medical and dental practice. |
| format | Article |
| id | doaj-art-7d392ec145b1446caf46a07c9ec98ffd |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-7d392ec145b1446caf46a07c9ec98ffd2025-08-20T04:01:42ZengBMCBMC Oral Health1472-68312025-07-0125111210.1186/s12903-025-06481-6Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban settingAdeniyi Oluwadaisi0Oluwadare Ogunlade1Foluso Owotade2Elijah Olufemi Oyetola3Adetayo Aborisade4Asafa Muritala Abiola5Department of Pathology and Oral Medicine, Faculty of Dentistry, Obafemi Awolowo UniversityDepartment of Physiological Sciences, Faculty of Basic Medical sciences, Obafemi Awolowo UniversityDepartment of Pathology and Oral Medicine, Faculty of Dentistry, Obafemi Awolowo UniversityDepartment of Pathology and Oral Medicine, Faculty of Dentistry, Obafemi Awolowo UniversityDepartment of Oral Diagnostic Sciences, Bayero UniversityDepartment of Physiological Sciences, Faculty of Basic Medical sciences, Obafemi Awolowo UniversityAbstract Background Despite the interconnectedness of oral health and the cardiometabolic syndrome (CMS), the role of oral parameters in diagnosing and predicting CMS risk has been underexplored, particularly in African populations. This study aims to investigate the relationships between oral parameters and CMS risk as a noninvasive means of screening and diagnosis. Methods The study utilized an observational study design. Oral health parameters, anthropometry indices, blood pressure profiles and laboratory indicators of adults with CMS were compared with healthy controls. The relationships of the dental caries, periodontal index, neck circumference, salivary oxidative index of Ferric-Reducing Antioxidant Power (FRAP) and uric acid with variables related to cardiometabolic syndrome in the study group and controls were analyzed. Results Besides height of respondents, all anthropometric variables of weight, BMI, neck and waist circumference were significantly higher in the CMS group (p < 0.001). Saliva pH in CMS participants at 6.90 was significantly lower than the pH of the control group at 7.00 (p = 0.018) while the salivary uric acid level in the CMS group at 4.14 was significantly greater than in “Control” group at 3.06 (p = 0.018). The mean salivary FRAP was significantly greater in the saliva of CMS subjects than in controls (p < 0.001). Similarly, there were also significant differences between the median serum uric acid values(p = 0.002) and serum FRAP scores (p < 0.001). The mean Decayed, Missing and Filled Teeth (DMFT) value for CMS was significantly higher at 1.04 ± 1.13 than that of controls at (0.43 ± 0.73) (p < 0.001) while the Periodontal Inflamed Surface Area (PISA) were also significantly higher (p < 0.001) in CMS patients at 169.43 ± 91.71 mm2 compared to controls (62.28 ± 38.23 mm2). Regression analysis showed salivary, and serum FRAP had odds ratio of 2.39 and 5.39 respectively. Conclusion In this study, dental caries was significantly associated with cardiometabolic syndrome. Similarly, the periodontal inflamed surface area index was positively associated with the CMS compared with the control. Salivary and serum oxidative stress (uric acid and FRAP) values were significantly related in patients with CMS compared with controls. The study concluded that oral health parameters and anthropometric parameters can be excellent noninvasive tools for assessing cardiometabolic risk in community medical and dental practice.https://doi.org/10.1186/s12903-025-06481-6Cardiometabolic syndromeFerric reducing antioxidant powerUric acidPeriodontal inflamed surface area |
| spellingShingle | Adeniyi Oluwadaisi Oluwadare Ogunlade Foluso Owotade Elijah Olufemi Oyetola Adetayo Aborisade Asafa Muritala Abiola Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting BMC Oral Health Cardiometabolic syndrome Ferric reducing antioxidant power Uric acid Periodontal inflamed surface area |
| title | Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting |
| title_full | Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting |
| title_fullStr | Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting |
| title_full_unstemmed | Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting |
| title_short | Caries experience, periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a Nigerian suburban setting |
| title_sort | caries experience periodontal disease and salivary antioxidants as biomarkers of cardiometabolic syndrome among hospital attendees in a nigerian suburban setting |
| topic | Cardiometabolic syndrome Ferric reducing antioxidant power Uric acid Periodontal inflamed surface area |
| url | https://doi.org/10.1186/s12903-025-06481-6 |
| work_keys_str_mv | AT adeniyioluwadaisi cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting AT oluwadareogunlade cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting AT folusoowotade cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting AT elijaholufemioyetola cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting AT adetayoaborisade cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting AT asafamuritalaabiola cariesexperienceperiodontaldiseaseandsalivaryantioxidantsasbiomarkersofcardiometabolicsyndromeamonghospitalattendeesinanigeriansuburbansetting |