Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study
Aims. The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing the expression of CD-68, Bcl-2, and β-catenin. Methods. H and E stained sections showed large odontogenic islands sh...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2013/372781 |
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| author | Santosh Hunasgi Anila Koneru Dinesh Singh Chauhan Yadavalli Guruprasad |
| author_facet | Santosh Hunasgi Anila Koneru Dinesh Singh Chauhan Yadavalli Guruprasad |
| author_sort | Santosh Hunasgi |
| collection | DOAJ |
| description | Aims. The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing the expression of CD-68, Bcl-2, and β-catenin. Methods. H and E stained sections showed large odontogenic islands showing peripheral ameloblast-like cells and central stellate reticulum-like cells with extensive granular cell transformation surrounded by fibrous stroma. Polyclonal rabbit anti-CD 68, anti-Bcl2, and anti-β-catenin were stained immunohistochemically. Results. CD-68 showed a moderate to strong staining intensity in granular cells. Moderate staining of Bcl-2 was expressed by the peripheral columnar cells of tumor islands and negative in the granular cells. Expression of β-catenin was generally weak, except for only the focal areas that showed a moderate staining intensity and weak in peripheral cells. Conclusion. The present case of giant granular cell ameloblastoma is a rare entity. Development of monstrous size is indicative of ameloblastomas persistent growth. Granular cell transformation in ameloblastomas probably occurs as a consequence of extensive molecular changes. Immunohistochemical studies help us to know the pathogenesis of this granular cell ameloblastoma. Therefore, an effort has been made here to study the expression of Bcl-2, CD-68, and β-catenin. |
| format | Article |
| id | doaj-art-7d3843f2cffb49809d2aef7b85f4d97a |
| institution | OA Journals |
| issn | 2090-6447 2090-6455 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dentistry |
| spelling | doaj-art-7d3843f2cffb49809d2aef7b85f4d97a2025-08-20T02:07:12ZengWileyCase Reports in Dentistry2090-64472090-64552013-01-01201310.1155/2013/372781372781Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical StudySantosh Hunasgi0Anila Koneru1Dinesh Singh Chauhan2Yadavalli Guruprasad3Department of Oral and Maxillofacial Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka 584103, IndiaDepartment of Oral and Maxillofacial Pathology, Navodaya Dental College and Hospital, Raichur, Karnataka 584103, IndiaDepartment of Oral and Maxillofacial Surgery, AME’s Dental College, Raichur, Karnataka 584103, IndiaDepartment of Oral and Maxillofacial Surgery, AME’s Dental College, Raichur, Karnataka 584103, IndiaAims. The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing the expression of CD-68, Bcl-2, and β-catenin. Methods. H and E stained sections showed large odontogenic islands showing peripheral ameloblast-like cells and central stellate reticulum-like cells with extensive granular cell transformation surrounded by fibrous stroma. Polyclonal rabbit anti-CD 68, anti-Bcl2, and anti-β-catenin were stained immunohistochemically. Results. CD-68 showed a moderate to strong staining intensity in granular cells. Moderate staining of Bcl-2 was expressed by the peripheral columnar cells of tumor islands and negative in the granular cells. Expression of β-catenin was generally weak, except for only the focal areas that showed a moderate staining intensity and weak in peripheral cells. Conclusion. The present case of giant granular cell ameloblastoma is a rare entity. Development of monstrous size is indicative of ameloblastomas persistent growth. Granular cell transformation in ameloblastomas probably occurs as a consequence of extensive molecular changes. Immunohistochemical studies help us to know the pathogenesis of this granular cell ameloblastoma. Therefore, an effort has been made here to study the expression of Bcl-2, CD-68, and β-catenin.http://dx.doi.org/10.1155/2013/372781 |
| spellingShingle | Santosh Hunasgi Anila Koneru Dinesh Singh Chauhan Yadavalli Guruprasad Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study Case Reports in Dentistry |
| title | Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study |
| title_full | Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study |
| title_fullStr | Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study |
| title_full_unstemmed | Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study |
| title_short | Rare Giant Granular Cell Ameloblastoma: A Case Report and an Immunohistochemical Study |
| title_sort | rare giant granular cell ameloblastoma a case report and an immunohistochemical study |
| url | http://dx.doi.org/10.1155/2013/372781 |
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