The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients

Background. In Parkinson’s disease (PD), dopamine deficiency is present not only in the nigrostriatal pathway but also in the retinal and visual pathways. Optic coherence tomography (OCT) can be used as morphological evidence of visual influence from early nonmotor symptoms. The aim of this study wa...

Full description

Saved in:
Bibliographic Details
Main Authors: Zeynep Tuncer, Gamze Dereli Can, Hava Dönmez Keklikoğlu, Fatma Ayşen Eren, Fatma Yülek, Orhan Deniz
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Parkinson's Disease
Online Access:http://dx.doi.org/10.1155/2023/7739944
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832547995171684352
author Zeynep Tuncer
Gamze Dereli Can
Hava Dönmez Keklikoğlu
Fatma Ayşen Eren
Fatma Yülek
Orhan Deniz
author_facet Zeynep Tuncer
Gamze Dereli Can
Hava Dönmez Keklikoğlu
Fatma Ayşen Eren
Fatma Yülek
Orhan Deniz
author_sort Zeynep Tuncer
collection DOAJ
description Background. In Parkinson’s disease (PD), dopamine deficiency is present not only in the nigrostriatal pathway but also in the retinal and visual pathways. Optic coherence tomography (OCT) can be used as morphological evidence of visual influence from early nonmotor symptoms. The aim of this study was to investigate the relationship of OCT and visual evoked potentials (VEPs) of eyes with the severity of clinical findings and ocular findings in PD. Methods. A group of 42 patients diagnosed with idiopathic PD and a control group of 29 people between the ages of 45–85 were included in our study. VEP was recorded in the patient and control groups. OCT measurement was made with the Optovue spectral-domain device. Foveal thickness and macular volume were measured in the foveal region and in the parafoveal and perifoveal regions in the temporal, superior, nasal, and inferior quadrants. RNFL (retinal nerve fiber layer) was measured in temporal, superior, nasal, and inferior quadrants. Ganglion cell complex (GCC) was evaluated in the superior and inferior quadrants. Using the UPDRS clinical scale, the relationship between measurements and the differences between the control group and the patient group were evaluated. Results. Among the OCT values in our study, foveal, parafoveal, perifoveal thickness, macular volume, RNFL, and GCC measurements were performed for the right and left eyes, and no difference was found between the patient group and the control group. There was no difference in VEP amplitude and latency values between the patient and control groups. The relationships between UPDRS and modified Hoehn Yahr staging and OCT and VEP measurements in the patient revealed no correlation. Conclusions. Studies on whether OCT measurements can functionally be a marker or which segments are more valuable for disease progression in patients with PD are needed. Visual dysfunction in PD cannot be attributed only to retinal pathology; however, the retina may provide monitoring of the status of dopaminergic neurodegeneration and axonal loss in PD.
format Article
id doaj-art-7d34b4962dc445f4a4eca1f183fea22a
institution Kabale University
issn 2042-0080
language English
publishDate 2023-01-01
publisher Wiley
record_format Article
series Parkinson's Disease
spelling doaj-art-7d34b4962dc445f4a4eca1f183fea22a2025-02-03T06:42:39ZengWileyParkinson's Disease2042-00802023-01-01202310.1155/2023/7739944The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson PatientsZeynep Tuncer0Gamze Dereli Can1Hava Dönmez Keklikoğlu2Fatma Ayşen Eren3Fatma Yülek4Orhan Deniz5Sakarya Adatıp HospitalDepartment of OphthalmologyDepartment of NeurologyDepartment of Neurology and Pain ManagementDepartment of OphthalmologyDepartment of NeurologyBackground. In Parkinson’s disease (PD), dopamine deficiency is present not only in the nigrostriatal pathway but also in the retinal and visual pathways. Optic coherence tomography (OCT) can be used as morphological evidence of visual influence from early nonmotor symptoms. The aim of this study was to investigate the relationship of OCT and visual evoked potentials (VEPs) of eyes with the severity of clinical findings and ocular findings in PD. Methods. A group of 42 patients diagnosed with idiopathic PD and a control group of 29 people between the ages of 45–85 were included in our study. VEP was recorded in the patient and control groups. OCT measurement was made with the Optovue spectral-domain device. Foveal thickness and macular volume were measured in the foveal region and in the parafoveal and perifoveal regions in the temporal, superior, nasal, and inferior quadrants. RNFL (retinal nerve fiber layer) was measured in temporal, superior, nasal, and inferior quadrants. Ganglion cell complex (GCC) was evaluated in the superior and inferior quadrants. Using the UPDRS clinical scale, the relationship between measurements and the differences between the control group and the patient group were evaluated. Results. Among the OCT values in our study, foveal, parafoveal, perifoveal thickness, macular volume, RNFL, and GCC measurements were performed for the right and left eyes, and no difference was found between the patient group and the control group. There was no difference in VEP amplitude and latency values between the patient and control groups. The relationships between UPDRS and modified Hoehn Yahr staging and OCT and VEP measurements in the patient revealed no correlation. Conclusions. Studies on whether OCT measurements can functionally be a marker or which segments are more valuable for disease progression in patients with PD are needed. Visual dysfunction in PD cannot be attributed only to retinal pathology; however, the retina may provide monitoring of the status of dopaminergic neurodegeneration and axonal loss in PD.http://dx.doi.org/10.1155/2023/7739944
spellingShingle Zeynep Tuncer
Gamze Dereli Can
Hava Dönmez Keklikoğlu
Fatma Ayşen Eren
Fatma Yülek
Orhan Deniz
The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
Parkinson's Disease
title The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
title_full The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
title_fullStr The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
title_full_unstemmed The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
title_short The Relationship between Visual-Evoked Potential and Optic Coherence Tomography and Clinical Findings in Parkinson Patients
title_sort relationship between visual evoked potential and optic coherence tomography and clinical findings in parkinson patients
url http://dx.doi.org/10.1155/2023/7739944
work_keys_str_mv AT zeyneptuncer therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT gamzederelican therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT havadonmezkeklikoglu therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT fatmaayseneren therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT fatmayulek therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT orhandeniz therelationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT zeyneptuncer relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT gamzederelican relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT havadonmezkeklikoglu relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT fatmaayseneren relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT fatmayulek relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients
AT orhandeniz relationshipbetweenvisualevokedpotentialandopticcoherencetomographyandclinicalfindingsinparkinsonpatients