Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis
Xiaoxi Shi,* Xiaojia Zhu,* Haoxiang Zhang, Yanjie Wang, Xueping Qi, Fengli Cheng, Danni Xu, Luyao Wang, Hongying Duan, Changqing Zhao Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of Ch...
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Dove Medical Press
2025-05-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/bibliometric-analysis-on-the-central-regulation-of-airway-allergic-hyp-peer-reviewed-fulltext-article-JAA |
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| author | Shi X Zhu X Zhang H Wang Y Qi X Cheng F Xu D Wang L Duan H Zhao C |
| author_facet | Shi X Zhu X Zhang H Wang Y Qi X Cheng F Xu D Wang L Duan H Zhao C |
| author_sort | Shi X |
| collection | DOAJ |
| description | Xiaoxi Shi,* Xiaojia Zhu,* Haoxiang Zhang, Yanjie Wang, Xueping Qi, Fengli Cheng, Danni Xu, Luyao Wang, Hongying Duan, Changqing Zhao Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Changqing Zhao, No.382, Wuyi Street, Taiyuan, Shanxi, 030000, People’s Republic of China, Email fahyj@126.comAim: This study aimed to systematically analyze the neuro-regulation mechanisms of airway hyperreactivity disease using bibliometrics, focusing on the research status and progress of two key regulatory networks: the “lung-brain axis” and the “nasal-brain axis”, to further characterize the “nasal-brain axis”.Methods: A bibliometric analysis of 626 articles published between 1991 and 2024 was conducted to assess the growing interest in the impact of neuro-immune mechanisms and psychological stress on airway diseases, including asthma and allergic rhinitis (AR).Results: The study findings revealed that interactions between neuro-immune signaling pathways and the central nervous system are crucial for understanding airway hyperreactivity, with the United States leading research contributions. Key themes identified in this study include allergic asthma, neuroinflammation, and the lung-brain axis, revealing bidirectional communication pathways between peripheral and central immune responses.Conclusion: Based on studies of asthma and the lung-brain axis, we anticipate that AR and the nasal-brain axis likely involve similar neuro-immune mechanisms and peripheral-central response circuits. The nasal-brain axis theory was further supported by its integration with the unified airway hypothesis, solidifying its role as a crucial regulatory mechanism in airway inflammation research.Keywords: airway hyperreactivity, central regulation, lung-brain axis, nasal-brain axis, neuro-immune, bibliometrics visualization |
| format | Article |
| id | doaj-art-7d332a65feec45008bf2921f3a1f76e0 |
| institution | Kabale University |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj-art-7d332a65feec45008bf2921f3a1f76e02025-08-20T03:32:36ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-05-01Volume 18Issue 1877890103492Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain AxisShi X0Zhu XZhang H1Wang Y2Qi XCheng FXu DWang LDuan HZhao C3The Second Hospital of Shanxi Medical UniversityThe Second Hospital of Shanxi Medical Universitysecond hospital , shanxi medical universityThe Second Hospital of Shanxi Medical UniversityXiaoxi Shi,* Xiaojia Zhu,* Haoxiang Zhang, Yanjie Wang, Xueping Qi, Fengli Cheng, Danni Xu, Luyao Wang, Hongying Duan, Changqing Zhao Department of Otolaryngology-Head and Neck Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Changqing Zhao, No.382, Wuyi Street, Taiyuan, Shanxi, 030000, People’s Republic of China, Email fahyj@126.comAim: This study aimed to systematically analyze the neuro-regulation mechanisms of airway hyperreactivity disease using bibliometrics, focusing on the research status and progress of two key regulatory networks: the “lung-brain axis” and the “nasal-brain axis”, to further characterize the “nasal-brain axis”.Methods: A bibliometric analysis of 626 articles published between 1991 and 2024 was conducted to assess the growing interest in the impact of neuro-immune mechanisms and psychological stress on airway diseases, including asthma and allergic rhinitis (AR).Results: The study findings revealed that interactions between neuro-immune signaling pathways and the central nervous system are crucial for understanding airway hyperreactivity, with the United States leading research contributions. Key themes identified in this study include allergic asthma, neuroinflammation, and the lung-brain axis, revealing bidirectional communication pathways between peripheral and central immune responses.Conclusion: Based on studies of asthma and the lung-brain axis, we anticipate that AR and the nasal-brain axis likely involve similar neuro-immune mechanisms and peripheral-central response circuits. The nasal-brain axis theory was further supported by its integration with the unified airway hypothesis, solidifying its role as a crucial regulatory mechanism in airway inflammation research.Keywords: airway hyperreactivity, central regulation, lung-brain axis, nasal-brain axis, neuro-immune, bibliometrics visualizationhttps://www.dovepress.com/bibliometric-analysis-on-the-central-regulation-of-airway-allergic-hyp-peer-reviewed-fulltext-article-JAAAirway HyperreactivityCentral RegulationLung-brain AxisNasal-brain AxisNeuro-ImmuneBibliometrics Visualization |
| spellingShingle | Shi X Zhu X Zhang H Wang Y Qi X Cheng F Xu D Wang L Duan H Zhao C Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis Journal of Asthma and Allergy Airway Hyperreactivity Central Regulation Lung-brain Axis Nasal-brain Axis Neuro-Immune Bibliometrics Visualization |
| title | Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis |
| title_full | Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis |
| title_fullStr | Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis |
| title_full_unstemmed | Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis |
| title_short | Bibliometric Analysis on the Central Regulation of Airway Allergic Hyperreactivity Diseases Based on Bibliometric Analysis: From Lung-Brain Axis to Nasal-Brain Axis |
| title_sort | bibliometric analysis on the central regulation of airway allergic hyperreactivity diseases based on bibliometric analysis from lung brain axis to nasal brain axis |
| topic | Airway Hyperreactivity Central Regulation Lung-brain Axis Nasal-brain Axis Neuro-Immune Bibliometrics Visualization |
| url | https://www.dovepress.com/bibliometric-analysis-on-the-central-regulation-of-airway-allergic-hyp-peer-reviewed-fulltext-article-JAA |
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