The interrelated roles of RAB family proteins in the advancement of neoplastic growth
Rab Proteins, A Subfamily Of The Ras Superfamily Of Small Gtpases, Are Critical Regulators Of Intracellular Vesicular Trafficking, Which Is Intricately Linked To Various Cellular Processes. These Proteins Play Essential Roles Not Only In Maintaining Cellular Homeostasis But Also In Mediating The Com...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1513360/full |
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| author | Yuxin Ji Yuxin Ji Ruonan Li Ruonan Li Guohui Tang Guohui Tang Wenrui Wang Wenrui Wang Changjie Chen Changjie Chen Qingling Yang Qingling Yang Qingling Yang |
| author_facet | Yuxin Ji Yuxin Ji Ruonan Li Ruonan Li Guohui Tang Guohui Tang Wenrui Wang Wenrui Wang Changjie Chen Changjie Chen Qingling Yang Qingling Yang Qingling Yang |
| author_sort | Yuxin Ji |
| collection | DOAJ |
| description | Rab Proteins, A Subfamily Of The Ras Superfamily Of Small Gtpases, Are Critical Regulators Of Intracellular Vesicular Trafficking, Which Is Intricately Linked To Various Cellular Processes. These Proteins Play Essential Roles Not Only In Maintaining Cellular Homeostasis But Also In Mediating The Complex Interplay Between Cancer Cells and Their Microenvironment. Rab Proteins Can Act As Either Oncogenic Factors Or Tumor Suppressors, With Their Functions Highly Dependent On The Cellular Context. Mechanistic Studies Have Revealed That Rab Proteins Are Involved In A Variety Of Processes, Including Vesicular Transport, Tumor Microenvironment Regulation, Autophagy, Drug Resistance, and Metabolic Regulation, and Play Either A Promotional Or Inhibitory Role In Cancer Development. Consequently, Targeting Rab Gtpases To Restore Dysregulated Vesicular Transport Systems May Offer A Promising Therapeutic Strategy To Inhibit Cancer Progression. However, It Is Equally Important To Consider The Potential Risks Of Disrupting Rab Functions, As Their Roles Are Highly Context-Dependent and May Have Opposing Effects In Different Malignancies. This Review Focuses On The Multifaceted Involvement Of Rab Family Proteins In Cancer Progression Underscores Their Importance As Potential Therapeutic Targets and Underscores The Need For A Deeper Understanding Of Their Complex Roles In Tumorigenesis. |
| format | Article |
| id | doaj-art-7d3326b8975e4b67a9da0e79896bf853 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-7d3326b8975e4b67a9da0e79896bf8532025-08-20T01:48:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15133601513360The interrelated roles of RAB family proteins in the advancement of neoplastic growthYuxin Ji0Yuxin Ji1Ruonan Li2Ruonan Li3Guohui Tang4Guohui Tang5Wenrui Wang6Wenrui Wang7Changjie Chen8Changjie Chen9Qingling Yang10Qingling Yang11Qingling Yang12Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaClinical Testing and Diagnose Experimental Center, Bengbu Medical University, Bengbu, Anhui, ChinaAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaClinical Testing and Diagnose Experimental Center, Bengbu Medical University, Bengbu, Anhui, ChinaAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Biotechnology, Bengbu Medical College, Bengbu, Anhui, ChinaAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Biotechnology, Bengbu Medical College, Bengbu, Anhui, ChinaAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaDepartment of Biotechnology, Bengbu Medical College, Bengbu, Anhui, ChinaAnhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, ChinaClinical Testing and Diagnose Experimental Center, Bengbu Medical University, Bengbu, Anhui, ChinaInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, ChinaRab Proteins, A Subfamily Of The Ras Superfamily Of Small Gtpases, Are Critical Regulators Of Intracellular Vesicular Trafficking, Which Is Intricately Linked To Various Cellular Processes. These Proteins Play Essential Roles Not Only In Maintaining Cellular Homeostasis But Also In Mediating The Complex Interplay Between Cancer Cells and Their Microenvironment. Rab Proteins Can Act As Either Oncogenic Factors Or Tumor Suppressors, With Their Functions Highly Dependent On The Cellular Context. Mechanistic Studies Have Revealed That Rab Proteins Are Involved In A Variety Of Processes, Including Vesicular Transport, Tumor Microenvironment Regulation, Autophagy, Drug Resistance, and Metabolic Regulation, and Play Either A Promotional Or Inhibitory Role In Cancer Development. Consequently, Targeting Rab Gtpases To Restore Dysregulated Vesicular Transport Systems May Offer A Promising Therapeutic Strategy To Inhibit Cancer Progression. However, It Is Equally Important To Consider The Potential Risks Of Disrupting Rab Functions, As Their Roles Are Highly Context-Dependent and May Have Opposing Effects In Different Malignancies. This Review Focuses On The Multifaceted Involvement Of Rab Family Proteins In Cancer Progression Underscores Their Importance As Potential Therapeutic Targets and Underscores The Need For A Deeper Understanding Of Their Complex Roles In Tumorigenesis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1513360/fullRAB proteinscancer progressionvesicular traffickingglucose metabolismautophagydrug resistance |
| spellingShingle | Yuxin Ji Yuxin Ji Ruonan Li Ruonan Li Guohui Tang Guohui Tang Wenrui Wang Wenrui Wang Changjie Chen Changjie Chen Qingling Yang Qingling Yang Qingling Yang The interrelated roles of RAB family proteins in the advancement of neoplastic growth Frontiers in Oncology RAB proteins cancer progression vesicular trafficking glucose metabolism autophagy drug resistance |
| title | The interrelated roles of RAB family proteins in the advancement of neoplastic growth |
| title_full | The interrelated roles of RAB family proteins in the advancement of neoplastic growth |
| title_fullStr | The interrelated roles of RAB family proteins in the advancement of neoplastic growth |
| title_full_unstemmed | The interrelated roles of RAB family proteins in the advancement of neoplastic growth |
| title_short | The interrelated roles of RAB family proteins in the advancement of neoplastic growth |
| title_sort | interrelated roles of rab family proteins in the advancement of neoplastic growth |
| topic | RAB proteins cancer progression vesicular trafficking glucose metabolism autophagy drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1513360/full |
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