Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Abstract Background Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT)...

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Bibliographic Details
Main Authors:	Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Fluids and Barriers of the CNS
Subjects:	Blood–brain barrier VHH Myelin oligodendrocyte glycoprotein Transferrin receptor Brain half-life extension β-secretase 1
Online Access:	https://doi.org/10.1186/s12987-025-00624-1
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