Recent advances in dual response molecular probes for biothiols
Abstract The detection of biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are critical for understanding their roles in biology and their involvement in various physiological and pathological processes. Recently, significant progress has been made in constructing fluoresc...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | Smart Molecules |
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| Online Access: | https://doi.org/10.1002/smo.20240044 |
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| _version_ | 1850054383496069120 |
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| author | Master Mwafulirwa Khamis Abdalla Wenhai Bian Hongbei Wei Liren Xu Wanyi Yu Zhang Hui Qi Yang Xiaolong Sun |
| author_facet | Master Mwafulirwa Khamis Abdalla Wenhai Bian Hongbei Wei Liren Xu Wanyi Yu Zhang Hui Qi Yang Xiaolong Sun |
| author_sort | Master Mwafulirwa |
| collection | DOAJ |
| description | Abstract The detection of biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are critical for understanding their roles in biology and their involvement in various physiological and pathological processes. Recently, significant progress has been made in constructing fluorescent probes capable of detecting and visualizing biothiols. This review provides an in‐depth look at the latest advancements in simultaneous and selective molecular probes, focusing on developments over the last 5 years. We examine design techniques, sensing mechanisms, and imaging methods to assess their effectiveness and responsiveness to thiols. Additionally, we discuss the prevailing challenges and offer recommendations to address them. |
| format | Article |
| id | doaj-art-7d2c00d900384b269f7a36b2f6c2dc9e |
| institution | DOAJ |
| issn | 2751-4587 2751-4595 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Smart Molecules |
| spelling | doaj-art-7d2c00d900384b269f7a36b2f6c2dc9e2025-08-20T02:52:16ZengWileySmart Molecules2751-45872751-45952024-12-0124n/an/a10.1002/smo.20240044Recent advances in dual response molecular probes for biothiolsMaster Mwafulirwa0Khamis Abdalla1Wenhai Bian2Hongbei Wei3Liren Xu4Wanyi Yu5Zhang Hui6Qi Yang7Xiaolong Sun8The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an ChinaAbstract The detection of biothiols such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) are critical for understanding their roles in biology and their involvement in various physiological and pathological processes. Recently, significant progress has been made in constructing fluorescent probes capable of detecting and visualizing biothiols. This review provides an in‐depth look at the latest advancements in simultaneous and selective molecular probes, focusing on developments over the last 5 years. We examine design techniques, sensing mechanisms, and imaging methods to assess their effectiveness and responsiveness to thiols. Additionally, we discuss the prevailing challenges and offer recommendations to address them.https://doi.org/10.1002/smo.20240044biothiolsdiscriminative responsedual‐mode imagingfluorescent probefluorogenic detection |
| spellingShingle | Master Mwafulirwa Khamis Abdalla Wenhai Bian Hongbei Wei Liren Xu Wanyi Yu Zhang Hui Qi Yang Xiaolong Sun Recent advances in dual response molecular probes for biothiols Smart Molecules biothiols discriminative response dual‐mode imaging fluorescent probe fluorogenic detection |
| title | Recent advances in dual response molecular probes for biothiols |
| title_full | Recent advances in dual response molecular probes for biothiols |
| title_fullStr | Recent advances in dual response molecular probes for biothiols |
| title_full_unstemmed | Recent advances in dual response molecular probes for biothiols |
| title_short | Recent advances in dual response molecular probes for biothiols |
| title_sort | recent advances in dual response molecular probes for biothiols |
| topic | biothiols discriminative response dual‐mode imaging fluorescent probe fluorogenic detection |
| url | https://doi.org/10.1002/smo.20240044 |
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