Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia
High-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT rel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/31/10/451 |
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| author | Martina Canichella Matteo Molica Carla Mazzone Paolo de Fabritiis |
| author_facet | Martina Canichella Matteo Molica Carla Mazzone Paolo de Fabritiis |
| author_sort | Martina Canichella |
| collection | DOAJ |
| description | High-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. Results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions. |
| format | Article |
| id | doaj-art-7d2a0582d8b74d75be61630a44c107e4 |
| institution | OA Journals |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-7d2a0582d8b74d75be61630a44c107e42025-08-20T02:11:09ZengMDPI AGCurrent Oncology1198-00521718-77292024-10-0131106050606010.3390/curroncol31100451Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid LeukemiaMartina Canichella0Matteo Molica1Carla Mazzone2Paolo de Fabritiis3Hematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, ItalyDepartment of Hematology-Oncology, Azienda Ospedaliera Pugliese-Ciaccio, 88100 Catanzaro, ItalyHematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, ItalyHematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, ItalyHigh-risk acute myeloid leukemia has been associated with a poor outcome. Hematopoietic stem cell transplantation (HSCT) represents the only curative option for eligible patients. Relapse after HSCT is a dramatic event with poor chances of survival. With the aim of reducing the rate of post-HSCT relapse, maintenance treatment has been investigated in this setting. Results from clinical trials suggest an advantage in the use of a maintenance strategy; however, standardized guidelines are not yet available due to the lack of prospective clinical trials. In this review, we have reported the most important strategies adopted as post-HSCT maintenance, highlighting their efficacy, but the current research also opens questions.https://www.mdpi.com/1718-7729/31/10/451acute myeloid leukemia (AML)hematopoietic stem cell transplantation (HSCT)maintenance therapy post-HSCT in AMLtargeted drugscellular therapyhypometylating agents |
| spellingShingle | Martina Canichella Matteo Molica Carla Mazzone Paolo de Fabritiis Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Current Oncology acute myeloid leukemia (AML) hematopoietic stem cell transplantation (HSCT) maintenance therapy post-HSCT in AML targeted drugs cellular therapy hypometylating agents |
| title | Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_full | Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_fullStr | Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_full_unstemmed | Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_short | Maintenance Therapy Post-Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia |
| title_sort | maintenance therapy post hematopoietic stem cell transplantation in acute myeloid leukemia |
| topic | acute myeloid leukemia (AML) hematopoietic stem cell transplantation (HSCT) maintenance therapy post-HSCT in AML targeted drugs cellular therapy hypometylating agents |
| url | https://www.mdpi.com/1718-7729/31/10/451 |
| work_keys_str_mv | AT martinacanichella maintenancetherapyposthematopoieticstemcelltransplantationinacutemyeloidleukemia AT matteomolica maintenancetherapyposthematopoieticstemcelltransplantationinacutemyeloidleukemia AT carlamazzone maintenancetherapyposthematopoieticstemcelltransplantationinacutemyeloidleukemia AT paolodefabritiis maintenancetherapyposthematopoieticstemcelltransplantationinacutemyeloidleukemia |