Aberrant EZHIP expression drives tumorigenesis in osteosarcoma

Aberrant EZHIP expression drives tumorigenesis in osteosarcoma

Abstract Osteosarcomas (OS) are aggressive bone tumors known for their extensive structural variations and rare recurrent oncogenic driver mutations. In this study, we identify ectopic expression of the oncohistone-mimic EZHIP in 20% of patients across two independent OS cohorts. We demonstrate that...

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Main Authors: Wajih Jawhar, Geoffroy Danieau, Alva Annett, Takeaki Ishii, Andrea Bajic, Ana Castillo-Orozco, Brian Krug, Yara Faucher-Jabado, Justin Seyedmoomenkashi, Mostafa Saquib, Masoumeh Aghababazadeh, Marjan Khatami, Nadim Tawil, Damien Faury, Sungmi Jung, Ahmed Aoude, Robert E. Turcotte, Benjamin Ellezam, Thomas Sontag, Sylvie Langlois, Daniel Sinnett, Swneke D. Bailey, Lingxin Zhang, Dorothée Dal Soglio, Claudia L. Kleinman, Nada Jabado, Livia Garzia
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61558-8
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