Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry
Introduction: Cardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor. Objective: To investigate the prevalence and patterns of hypertension diagnosis and management in adult patients...
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Bioscientifica
2025-01-01
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| Series: | Endocrine Connections |
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| author | Shani A D Mathara Diddhenipothage Katharina J Beck Gayana Amiyangoda Jillian Bryce Luminita Cima Katya De Groote Yana Deyanova Evgenia Globa Gloria Herrmann Anders Juul Anna Sophie L Kjaer Anette Tønnes Pedersen Sukran Poyrazoglu Ursina Probst-Scheidegger Theo C J Sas Simona Fica Sumudu Nimali Seneviratne Justyna Karolina Witczak Elizabeth Orchard Jeremy W Tomlinson S Faisal Ahmed Helen E Turner |
| author_facet | Shani A D Mathara Diddhenipothage Katharina J Beck Gayana Amiyangoda Jillian Bryce Luminita Cima Katya De Groote Yana Deyanova Evgenia Globa Gloria Herrmann Anders Juul Anna Sophie L Kjaer Anette Tønnes Pedersen Sukran Poyrazoglu Ursina Probst-Scheidegger Theo C J Sas Simona Fica Sumudu Nimali Seneviratne Justyna Karolina Witczak Elizabeth Orchard Jeremy W Tomlinson S Faisal Ahmed Helen E Turner |
| author_sort | Shani A D Mathara Diddhenipothage |
| collection | DOAJ |
| description | Introduction: Cardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor. Objective: To investigate the prevalence and patterns of hypertension diagnosis and management in adult patients with TS who are registered in a large international multicentre database (TS-HTN study). Methods: Retrospective multicentre observational study of patients aged ≥18 years included in the I-TS (International-TS) registry (2020–2022), using registry and participating centre-collected data. Results: Twelve international centres participated, including 182 patients with a median age of 28 years (IQR 23–37.2). Arterial hypertension was recorded in 13.2% (n = 24). The median age at hypertension diagnosis was 27 years (range 10–56), with 92% aged less than 50 years at diagnosis. The majority (75%) were classified as primary hypertension (n = 18). In binomial regression analysis, higher body mass index was the only parameter significantly associated with the occurrence of hypertension (B = 1.487, P = 0.004). Among patients with aortic disease (n = 9), 50% had systolic BP ≥ 130 mmHg and 66.6% had diastolic BP ≥ 80 mmHg during the last clinic review. Angiotensin-converting enzyme inhibitors were the most common (n = 16) medication prescribed, followed by angiotensin receptor blockers (n = 6), beta-blockers (n = 6) and calcium channel blockers (n = 6). Conclusions: Arterial hypertension is common in TS and occurs at a young age. Overweight/obesity was a notable risk factor for hypertension. The frequency of suboptimal BP control among high-risk patients highlights the importance of increased awareness and TS-specific consensus guidance on management. |
| format | Article |
| id | doaj-art-7d24e9e963d241bdafdde388e35f0280 |
| institution | Kabale University |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Bioscientifica |
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| series | Endocrine Connections |
| spelling | doaj-art-7d24e9e963d241bdafdde388e35f02802025-01-25T14:58:58ZengBioscientificaEndocrine Connections2049-36142025-01-0114210.1530/EC-24-04771Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registryShani A D Mathara Diddhenipothage0Katharina J Beck1Gayana Amiyangoda2Jillian Bryce3Luminita Cima4Katya De Groote5Yana Deyanova6Evgenia Globa7Gloria Herrmann8Anders Juul9Anna Sophie L Kjaer10Anette Tønnes Pedersen11Sukran Poyrazoglu12Ursina Probst-Scheidegger13Theo C J Sas14Simona Fica15Sumudu Nimali Seneviratne16Justyna Karolina Witczak17Elizabeth Orchard18Jeremy W Tomlinson19S Faisal Ahmed20Helen E Turner21Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Trust, Oxford, UKOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Trust, Oxford, UKOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Trust, Oxford, UKDevelopmental Endocrinology Research Group, School of Medicine, University of Glasgow, Royal Hospital For Children, Office Block, Glasgow, UKEndocrinology Department Elias University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Pediatrics, Paediatric cardiology, Ghent University Hospital, Ghent, BelgiumDepartment of Pediatrics, Medical University of Varna, Varna, BulgariaDepartment of Pediatric endocrinology, Ukrainian Research Center of Endocrine Surgery, Endocrine Organs and Tissue Transplantation, MoH of Ukraine, Kyiv, UkraineDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, University Hospital Ulm, Ulm, GermanyDepartment of Growth and Reproduction and EDMaRC, Copenhagen University Hospital—Rigshospitalet, Copenhagen, DenmarkDepartment of Growth and Reproduction and EDMaRC, Copenhagen University Hospital—Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkPediatric Endocrinology Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, TurkeyPediatric Department, Kantonsspital Winterthur, Winterthur, SwitzerlandDepartment of Pediatrics, Division of Pediatric Endocrinology, Erasmus University Medical Center, Sophia Children’s Hospital, Rotterdam, The NetherlandsEndocrinology Department Elias University Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri LankaCentre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UKDepartment of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UKOxford Centre for Diabetes, Endocrinology, and Metabolism, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UKDevelopmental Endocrinology Research Group, School of Medicine, University of Glasgow, Royal Hospital For Children, Office Block, Glasgow, UKOxford Centre for Diabetes, Endocrinology and Metabolism, Oxford University Hospitals NHS Trust, Oxford, UKIntroduction: Cardiovascular disease is the most common cause of death in Turner syndrome (TS) for which arterial hypertension has a direct influence and is a key modifiable risk factor. Objective: To investigate the prevalence and patterns of hypertension diagnosis and management in adult patients with TS who are registered in a large international multicentre database (TS-HTN study). Methods: Retrospective multicentre observational study of patients aged ≥18 years included in the I-TS (International-TS) registry (2020–2022), using registry and participating centre-collected data. Results: Twelve international centres participated, including 182 patients with a median age of 28 years (IQR 23–37.2). Arterial hypertension was recorded in 13.2% (n = 24). The median age at hypertension diagnosis was 27 years (range 10–56), with 92% aged less than 50 years at diagnosis. The majority (75%) were classified as primary hypertension (n = 18). In binomial regression analysis, higher body mass index was the only parameter significantly associated with the occurrence of hypertension (B = 1.487, P = 0.004). Among patients with aortic disease (n = 9), 50% had systolic BP ≥ 130 mmHg and 66.6% had diastolic BP ≥ 80 mmHg during the last clinic review. Angiotensin-converting enzyme inhibitors were the most common (n = 16) medication prescribed, followed by angiotensin receptor blockers (n = 6), beta-blockers (n = 6) and calcium channel blockers (n = 6). Conclusions: Arterial hypertension is common in TS and occurs at a young age. Overweight/obesity was a notable risk factor for hypertension. The frequency of suboptimal BP control among high-risk patients highlights the importance of increased awareness and TS-specific consensus guidance on management.https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0477.xmlturner syndromeinternational turner syndrome registryhypertension |
| spellingShingle | Shani A D Mathara Diddhenipothage Katharina J Beck Gayana Amiyangoda Jillian Bryce Luminita Cima Katya De Groote Yana Deyanova Evgenia Globa Gloria Herrmann Anders Juul Anna Sophie L Kjaer Anette Tønnes Pedersen Sukran Poyrazoglu Ursina Probst-Scheidegger Theo C J Sas Simona Fica Sumudu Nimali Seneviratne Justyna Karolina Witczak Elizabeth Orchard Jeremy W Tomlinson S Faisal Ahmed Helen E Turner Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry Endocrine Connections turner syndrome international turner syndrome registry hypertension |
| title | Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry |
| title_full | Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry |
| title_fullStr | Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry |
| title_full_unstemmed | Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry |
| title_short | Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry |
| title_sort | prevalence and management of hypertension in turner syndrome data from the international turner syndrome i ts registry |
| topic | turner syndrome international turner syndrome registry hypertension |
| url | https://ec.bioscientifica.com/view/journals/ec/14/2/EC-24-0477.xml |
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