Animal models in biomedical research: Relevance of Drosophila melanogaster
Animal models have become veritable tools in gaining insight into the pathogenesis and progression of several human diseases. These models could range in complexity from Caenorhabditis elegans to non-human primates. With the aid of these animal models, a lot of new knowledge has been gained about se...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024176360 |
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| author | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Olusola Bolaji Adewale Jeremiah Unuofin Bidemi Emmanuel Ekundayo Monde Ntwasa Sogolo Lucky Lebelo |
| author_facet | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Olusola Bolaji Adewale Jeremiah Unuofin Bidemi Emmanuel Ekundayo Monde Ntwasa Sogolo Lucky Lebelo |
| author_sort | Olabisi Tajudeen Obafemi |
| collection | DOAJ |
| description | Animal models have become veritable tools in gaining insight into the pathogenesis and progression of several human diseases. These models could range in complexity from Caenorhabditis elegans to non-human primates. With the aid of these animal models, a lot of new knowledge has been gained about several diseases which otherwise would not have been possible. Most times, the utilization of these animal models is predicated on the level of homology they share with humans, which suggests that outcomes of studies using them could be extrapolated to humans. However, this has not always been the case. Drosophila melanogaster is becoming increasingly relevant as preferred model for understanding the biochemical basis of several human diseases. Apart from its relatively short lifespan, high fecundity and ease of rearing, the simplicity of its genome and lower redundancy of its genes when compared with vertebrate models, as well as availability of genetic tool kit for easy manipulation of its genome, have all contributed to its emergence as a valid animal model of human diseases. This review aimed at highlighting the contributions of selected animal models in biomedical research with a focus on the relevance of Drosophila melanogaster in understanding the biochemical basis of some diseases that have continued to plague mankind. |
| format | Article |
| id | doaj-art-7d212449bf1b45489bdd92b664716fe4 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-7d212449bf1b45489bdd92b664716fe42025-01-17T04:51:44ZengElsevierHeliyon2405-84402025-01-01111e41605Animal models in biomedical research: Relevance of Drosophila melanogasterOlabisi Tajudeen Obafemi0Ademola Olabode Ayeleso1Olusola Bolaji Adewale2Jeremiah Unuofin3Bidemi Emmanuel Ekundayo4Monde Ntwasa5Sogolo Lucky Lebelo6Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South Africa; Corresponding author. Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South Africa.Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South Africa; Biochemistry Programme, College of Agriculture, Engineering and Science, Bowen University, PMB 284, Iwo, Osun State, NigeriaDepartment of Chemical Sciences, Afe Babalola University, PMB 5454 Ado-Ekiti, NigeriaDepartment of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South AfricaDepartment of Chemical Sciences, Afe Babalola University, PMB 5454 Ado-Ekiti, NigeriaDepartment of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South AfricaDepartment of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South AfricaAnimal models have become veritable tools in gaining insight into the pathogenesis and progression of several human diseases. These models could range in complexity from Caenorhabditis elegans to non-human primates. With the aid of these animal models, a lot of new knowledge has been gained about several diseases which otherwise would not have been possible. Most times, the utilization of these animal models is predicated on the level of homology they share with humans, which suggests that outcomes of studies using them could be extrapolated to humans. However, this has not always been the case. Drosophila melanogaster is becoming increasingly relevant as preferred model for understanding the biochemical basis of several human diseases. Apart from its relatively short lifespan, high fecundity and ease of rearing, the simplicity of its genome and lower redundancy of its genes when compared with vertebrate models, as well as availability of genetic tool kit for easy manipulation of its genome, have all contributed to its emergence as a valid animal model of human diseases. This review aimed at highlighting the contributions of selected animal models in biomedical research with a focus on the relevance of Drosophila melanogaster in understanding the biochemical basis of some diseases that have continued to plague mankind.http://www.sciencedirect.com/science/article/pii/S2405844024176360BiochemicalHomologyDrosophila melanogasterDisease modelsPathogenesis |
| spellingShingle | Olabisi Tajudeen Obafemi Ademola Olabode Ayeleso Olusola Bolaji Adewale Jeremiah Unuofin Bidemi Emmanuel Ekundayo Monde Ntwasa Sogolo Lucky Lebelo Animal models in biomedical research: Relevance of Drosophila melanogaster Heliyon Biochemical Homology Drosophila melanogaster Disease models Pathogenesis |
| title | Animal models in biomedical research: Relevance of Drosophila melanogaster |
| title_full | Animal models in biomedical research: Relevance of Drosophila melanogaster |
| title_fullStr | Animal models in biomedical research: Relevance of Drosophila melanogaster |
| title_full_unstemmed | Animal models in biomedical research: Relevance of Drosophila melanogaster |
| title_short | Animal models in biomedical research: Relevance of Drosophila melanogaster |
| title_sort | animal models in biomedical research relevance of drosophila melanogaster |
| topic | Biochemical Homology Drosophila melanogaster Disease models Pathogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024176360 |
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