Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism
BackgroundDrug-induced Parkinsonism (DIP) is a secondary Parkinsonism with limited research on its hippocampal structural changes. This study explores hippocampal subfield volumes in DIP compared to Parkinson’s disease (PD) and healthy controls (HCs), investigating correlations with cognitive (Montr...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1566785/full |
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| author | Wei Zhou MengYue Tang Bo Cheng Ling Sun HongYu Lin Yang Fan Nian Liu Shushan Zhang |
| author_facet | Wei Zhou MengYue Tang Bo Cheng Ling Sun HongYu Lin Yang Fan Nian Liu Shushan Zhang |
| author_sort | Wei Zhou |
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| description | BackgroundDrug-induced Parkinsonism (DIP) is a secondary Parkinsonism with limited research on its hippocampal structural changes. This study explores hippocampal subfield volumes in DIP compared to Parkinson’s disease (PD) and healthy controls (HCs), investigating correlations with cognitive (Montreal Cognitive Assessment, MoCA), emotional (Hamilton Depression Rating Scale, HAMD; Hamilton Anxiety Rating Scale, HAMA), and motor (Unified Parkinson’s Disease Rating Scale, UPDRS) symptoms.MethodsA total of 19 DIP patients, 20 PD patients, and 20 HCs were enrolled. MRI-based hippocampal subfield volumes were assessed using FreeSurfer, and clinical scores were evaluated for cognitive, emotional, and motor functions. Statistical analyses compared group differences and examined correlations.ResultsSignificant atrophy was observed in the DIP group in multiple hippocampal subfields compared to HCs, including the presubiculum, subiculum, Granule cell and molecular layer of the dentate gyrus (GC-ML-DG), molecular_layer_HP, Cornu ammonis (CA) 1, CA4, hippocampal tail, and fimbria. MoCA scores positively correlated with volumes in bilateral hippocampus and subfields such as subiculum and CA4, while HAMD scores mainly showed negative correlations in both DIP and PD group. UPDRS scores revealed group-specific patterns, with DIP showing stronger associations between non-motor symptoms and hippocampal volume.ConclusionThis study first reported significant hippocampal subfield atrophy in DIP, distinct from PD, and links structural changes to cognitive, emotional, and motor impairments. These findings advance understanding of DIP pathophysiology and underscore the hippocampus’s role in non-motor symptoms. |
| format | Article |
| id | doaj-art-7d208b5968d24751bf4959f6b71839f5 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-7d208b5968d24751bf4959f6b71839f52025-08-20T03:28:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-07-011710.3389/fnagi.2025.15667851566785Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced ParkinsonismWei Zhou0MengYue Tang1Bo Cheng2Ling Sun3HongYu Lin4Yang Fan5Nian Liu6Shushan Zhang7Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaSichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Geriatrics, Nanchong Central Hospital, Nanchong, Sichuan, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaSichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaBackgroundDrug-induced Parkinsonism (DIP) is a secondary Parkinsonism with limited research on its hippocampal structural changes. This study explores hippocampal subfield volumes in DIP compared to Parkinson’s disease (PD) and healthy controls (HCs), investigating correlations with cognitive (Montreal Cognitive Assessment, MoCA), emotional (Hamilton Depression Rating Scale, HAMD; Hamilton Anxiety Rating Scale, HAMA), and motor (Unified Parkinson’s Disease Rating Scale, UPDRS) symptoms.MethodsA total of 19 DIP patients, 20 PD patients, and 20 HCs were enrolled. MRI-based hippocampal subfield volumes were assessed using FreeSurfer, and clinical scores were evaluated for cognitive, emotional, and motor functions. Statistical analyses compared group differences and examined correlations.ResultsSignificant atrophy was observed in the DIP group in multiple hippocampal subfields compared to HCs, including the presubiculum, subiculum, Granule cell and molecular layer of the dentate gyrus (GC-ML-DG), molecular_layer_HP, Cornu ammonis (CA) 1, CA4, hippocampal tail, and fimbria. MoCA scores positively correlated with volumes in bilateral hippocampus and subfields such as subiculum and CA4, while HAMD scores mainly showed negative correlations in both DIP and PD group. UPDRS scores revealed group-specific patterns, with DIP showing stronger associations between non-motor symptoms and hippocampal volume.ConclusionThis study first reported significant hippocampal subfield atrophy in DIP, distinct from PD, and links structural changes to cognitive, emotional, and motor impairments. These findings advance understanding of DIP pathophysiology and underscore the hippocampus’s role in non-motor symptoms.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1566785/fullDrug-induced ParkinsonismParkinson’s diseasehippocampussubfieldscognitive impairment |
| spellingShingle | Wei Zhou MengYue Tang Bo Cheng Ling Sun HongYu Lin Yang Fan Nian Liu Shushan Zhang Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism Frontiers in Aging Neuroscience Drug-induced Parkinsonism Parkinson’s disease hippocampus subfields cognitive impairment |
| title | Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism |
| title_full | Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism |
| title_fullStr | Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism |
| title_full_unstemmed | Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism |
| title_short | Exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug-induced Parkinsonism |
| title_sort | exploring cognitive and emotional symptoms associated with hippocampal subfield atrophy in drug induced parkinsonism |
| topic | Drug-induced Parkinsonism Parkinson’s disease hippocampus subfields cognitive impairment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1566785/full |
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