Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis
Background: Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of SSc and cytokines can contribute to the disease pathology. This study aimed to determine relatio...
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Kashan University of Medical Sciences
2023-05-01
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| Series: | مجله علوم پزشکی فیض (پیوسته) |
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| Online Access: | http://feyz.kaums.ac.ir/article-1-4727-en.pdf |
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| author | Batool Zamani Kamal Esalatmanesh Ahmad Piroozmand seyyed Alireza Moravveji Elham Kolbedary |
| author_facet | Batool Zamani Kamal Esalatmanesh Ahmad Piroozmand seyyed Alireza Moravveji Elham Kolbedary |
| author_sort | Batool Zamani |
| collection | DOAJ |
| description | Background: Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of SSc and cytokines can contribute to the disease pathology. This study aimed to determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in SSc.
Materials and Methods: After obtaining consent, demographic data and serum levels of interleukin-6 were determined in 30 SSc with (case) and 30 without pulmonary involvement (control). Duration and activity status of disease, C-reactive protein (CRP), Chest x-ray and high resolution CT-scan (HRCT), ejection fraction (EF) and echocardiography findings and pulmonary artery pressure (PAP) were determined in two groups. Data analyzed with Mann-Whitney test, Chi-square test and Fisher’s exact test.
Results: Mean age of case and control group ranged 52.5±9.3 and 43.9±9.7 years respectively (P=0.001). The serum levels of IL-6 in case and control groups were 73.1±95.4 and 46.7±83.6 pg/ml (P=0.267), respectively. IL-6 levels was significantly higher in male case compared to male control (P=0.007). Duration of SSc in case and control groups was 11.6±6.4 and 7.4±4.2 years (P=0.002). Also Quantitative CRP and PAP was significantly higher in case (P=0.01 and P<0.001, respectively). In the Case group 66.7% of them had reticulo-nodular pattern, whereas 28 (93.3%) of control had normal CXR (P<0.001).
Conclusion: In SSc with pulmonary involvement serum, IL-6 levels is higher than without involvement but not statistically significant. Also, the CRP and PAP are benefit for evaluation of pulmonary involvement. |
| format | Article |
| id | doaj-art-7d1cb97d07b54c24bc0d57fdb77c9e2d |
| institution | OA Journals |
| issn | 3060-5806 3060-5814 |
| language | fas |
| publishDate | 2023-05-01 |
| publisher | Kashan University of Medical Sciences |
| record_format | Article |
| series | مجله علوم پزشکی فیض (پیوسته) |
| spelling | doaj-art-7d1cb97d07b54c24bc0d57fdb77c9e2d2025-08-20T02:26:20ZfasKashan University of Medical Sciencesمجله علوم پزشکی فیض (پیوسته)3060-58063060-58142023-05-01272202210Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosisBatool Zamani0Kamal Esalatmanesh1Ahmad Piroozmand2seyyed Alireza Moravveji3Elham Kolbedary4 Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran. Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran. Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran. Department of Social Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran. Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran. Background: Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of SSc and cytokines can contribute to the disease pathology. This study aimed to determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in SSc. Materials and Methods: After obtaining consent, demographic data and serum levels of interleukin-6 were determined in 30 SSc with (case) and 30 without pulmonary involvement (control). Duration and activity status of disease, C-reactive protein (CRP), Chest x-ray and high resolution CT-scan (HRCT), ejection fraction (EF) and echocardiography findings and pulmonary artery pressure (PAP) were determined in two groups. Data analyzed with Mann-Whitney test, Chi-square test and Fisher’s exact test. Results: Mean age of case and control group ranged 52.5±9.3 and 43.9±9.7 years respectively (P=0.001). The serum levels of IL-6 in case and control groups were 73.1±95.4 and 46.7±83.6 pg/ml (P=0.267), respectively. IL-6 levels was significantly higher in male case compared to male control (P=0.007). Duration of SSc in case and control groups was 11.6±6.4 and 7.4±4.2 years (P=0.002). Also Quantitative CRP and PAP was significantly higher in case (P=0.01 and P<0.001, respectively). In the Case group 66.7% of them had reticulo-nodular pattern, whereas 28 (93.3%) of control had normal CXR (P<0.001). Conclusion: In SSc with pulmonary involvement serum, IL-6 levels is higher than without involvement but not statistically significant. Also, the CRP and PAP are benefit for evaluation of pulmonary involvement.http://feyz.kaums.ac.ir/article-1-4727-en.pdfsystemic sclerosisinterstitial lung diseaseinterleukin-6crppap |
| spellingShingle | Batool Zamani Kamal Esalatmanesh Ahmad Piroozmand seyyed Alireza Moravveji Elham Kolbedary Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis مجله علوم پزشکی فیض (پیوسته) systemic sclerosis interstitial lung disease interleukin-6 crp pap |
| title | Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis |
| title_full | Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis |
| title_fullStr | Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis |
| title_full_unstemmed | Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis |
| title_short | Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis |
| title_sort | determine relation between serum levels of interleukin 6 and crp with pulmonary involvement in progressive systemic sclerosis |
| topic | systemic sclerosis interstitial lung disease interleukin-6 crp pap |
| url | http://feyz.kaums.ac.ir/article-1-4727-en.pdf |
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