The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

Human cytomegalovirus (HCMV) is a relevant pathogen, especially for individuals with impaired immunity. Harnessing potent immune antagonists, HCMV circumvents sterile immunity. Given that HCMV prevents the upregulation of human leukocyte antigen (HLA)-DP and HLA-DR, we screened a library of HCMV gen...

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Bibliographic Details
Main Authors: Fabienne Maassen, Vu Thuy Khanh Le-Trilling, Luisa Betke, Thilo Bracht, Corinna Siegmund, Malte Bayer, Benjamin Katschinski, Antonia Belter, Tanja Becker, Denise Mennerich, Sebastian Voigt, Lori Frappier, Barbara Sitek, Katharina Fleischhauer, Mirko Trilling
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
Human cytomegalovirus
HCMV
human herpesvirus 5
HHV-5
US28
HLA class II
Online Access:https://elifesciences.org/articles/96414
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