Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock
Background/objectivesBurns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological chang...
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Frontiers Media S.A.
2025-08-01
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| author | Xiang-Yu Liu Xiang-Yu Liu Yu-Shou Wu Yu-Shou Wu Yi-Rui Qu Yi-Rui Qu Hui Zhou Hui Zhou Tian Liu Xiao-Wei Su Xiao-Wei Su Fang-Chao Hu Fang-Chao Hu Jin-Guang Zheng Shao-Fang Han Jia-Ke Chai Yun-Fei Chi |
| author_facet | Xiang-Yu Liu Xiang-Yu Liu Yu-Shou Wu Yu-Shou Wu Yi-Rui Qu Yi-Rui Qu Hui Zhou Hui Zhou Tian Liu Xiao-Wei Su Xiao-Wei Su Fang-Chao Hu Fang-Chao Hu Jin-Guang Zheng Shao-Fang Han Jia-Ke Chai Yun-Fei Chi |
| author_sort | Xiang-Yu Liu |
| collection | DOAJ |
| description | Background/objectivesBurns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological changes in patients with burns. This study aimed to identify and evaluate several drugs that enhance the ORT efficacy in burn shock management.MethodsA systematic search of PubMed, Web of Science, and Scopus (2000.01.01–2024.06.30) yielded 1,500 relevant studies, from which 270 were selected for bibliometric analysis. Drug candidates (≥3 mentions) were prioritized via the Bibliometric Evidence Score (BES) integrating publication frequency, journal impact factor (5-year average), impact score, and Q1 journal distribution. Subsequently, the translational potential of these candidates was assessed using an Integrated Translational Score incorporating weighted dimensions: Mechanistic Clinical Alignment Score (weight = 0.45), Emergency Deployment Feasibility (weight = 0.20), and BES (weight = 0.35). The top 10 drugs by the BES were selected for experimental validation, which were tested in a rat model with 50% total body surface area full-thickness burns (n = 286, 22/group), comparing sham controls, untreated controls, WHO-ORS, and drug-adjuvanted ORS groups. Primary outcomes included 48 h survival rate and blood lactate (Lac), hematocrit (HCT), malondialdehyde (MDA), and interleukin-6 (IL-6) levels.ResultsTeprenone or vitamin C in combination with the WHO-ORS significantly improved survival outcomes following severe burns. They reduced blood lactate, HCT, MDA, and IL-6 levels. Glutamine and ethyl pyruvate showed beneficial effects but did not significantly improve survival. Hypertonic Saline and Dobutamine failed to demonstrate efficacy.ConclusionThis study demonstrated that adding teprenone or vitamin C to the WHO-recommended ORS can enhance the therapeutic efficacy of ORT in managing burn shock. These findings provide a scientific basis for further clinical trials and development of optimized ORS for patients with burns. |
| format | Article |
| id | doaj-art-7d0e004abd004b9d91b98a03cc50a10f |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-7d0e004abd004b9d91b98a03cc50a10f2025-08-20T03:07:19ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.16141591614159Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shockXiang-Yu Liu0Xiang-Yu Liu1Yu-Shou Wu2Yu-Shou Wu3Yi-Rui Qu4Yi-Rui Qu5Hui Zhou6Hui Zhou7Tian Liu8Xiao-Wei Su9Xiao-Wei Su10Fang-Chao Hu11Fang-Chao Hu12Jin-Guang Zheng13Shao-Fang Han14Jia-Ke Chai15Yun-Fei Chi16Graduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaGraduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaGraduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaGraduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaGraduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaGraduate School, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaSenior Department of Burns & Plastic Surgery, Institute of Burn in the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, ChinaBackground/objectivesBurns can cause severe physiological disturbances. Oral rehydration therapy (ORT) is an alternative to intravenous fluids. However, the World Health Organization-recommended oral rehydration solution (WHO-ORS) lacks specific components to address the critical physiological changes in patients with burns. This study aimed to identify and evaluate several drugs that enhance the ORT efficacy in burn shock management.MethodsA systematic search of PubMed, Web of Science, and Scopus (2000.01.01–2024.06.30) yielded 1,500 relevant studies, from which 270 were selected for bibliometric analysis. Drug candidates (≥3 mentions) were prioritized via the Bibliometric Evidence Score (BES) integrating publication frequency, journal impact factor (5-year average), impact score, and Q1 journal distribution. Subsequently, the translational potential of these candidates was assessed using an Integrated Translational Score incorporating weighted dimensions: Mechanistic Clinical Alignment Score (weight = 0.45), Emergency Deployment Feasibility (weight = 0.20), and BES (weight = 0.35). The top 10 drugs by the BES were selected for experimental validation, which were tested in a rat model with 50% total body surface area full-thickness burns (n = 286, 22/group), comparing sham controls, untreated controls, WHO-ORS, and drug-adjuvanted ORS groups. Primary outcomes included 48 h survival rate and blood lactate (Lac), hematocrit (HCT), malondialdehyde (MDA), and interleukin-6 (IL-6) levels.ResultsTeprenone or vitamin C in combination with the WHO-ORS significantly improved survival outcomes following severe burns. They reduced blood lactate, HCT, MDA, and IL-6 levels. Glutamine and ethyl pyruvate showed beneficial effects but did not significantly improve survival. Hypertonic Saline and Dobutamine failed to demonstrate efficacy.ConclusionThis study demonstrated that adding teprenone or vitamin C to the WHO-recommended ORS can enhance the therapeutic efficacy of ORT in managing burn shock. These findings provide a scientific basis for further clinical trials and development of optimized ORS for patients with burns.https://www.frontiersin.org/articles/10.3389/fphar.2025.1614159/fullburnshockoral rehydration therapyworld health organization-recommended oral rehydration solutiondrug screeningbibliometric analysis |
| spellingShingle | Xiang-Yu Liu Xiang-Yu Liu Yu-Shou Wu Yu-Shou Wu Yi-Rui Qu Yi-Rui Qu Hui Zhou Hui Zhou Tian Liu Xiao-Wei Su Xiao-Wei Su Fang-Chao Hu Fang-Chao Hu Jin-Guang Zheng Shao-Fang Han Jia-Ke Chai Yun-Fei Chi Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock Frontiers in Pharmacology burn shock oral rehydration therapy world health organization-recommended oral rehydration solution drug screening bibliometric analysis |
| title | Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock |
| title_full | Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock |
| title_fullStr | Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock |
| title_full_unstemmed | Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock |
| title_short | Bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post-burn shock |
| title_sort | bibliometric analysis and initial animal efficacy evaluation of top ten scoring drugs to enhance oral rehydration therapy in early post burn shock |
| topic | burn shock oral rehydration therapy world health organization-recommended oral rehydration solution drug screening bibliometric analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1614159/full |
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