Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014
Background: With ageing and lifestyle changes, the coexistence of osteoporosis and type 2 diabetes (T2DM) is becoming more common, which greatly increases patient disability and mortality. However, the association of low bone mineral density (BMD) with cardiovascular disease (CVD)...
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IMR Press
2024-12-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512434 |
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| author | Haipeng Li Baolong Wang Dongshuo Xu Jialu Zhang Changhui Wang |
| author_facet | Haipeng Li Baolong Wang Dongshuo Xu Jialu Zhang Changhui Wang |
| author_sort | Haipeng Li |
| collection | DOAJ |
| description | Background: With ageing and lifestyle changes, the coexistence of osteoporosis and type 2 diabetes (T2DM) is becoming more common, which greatly increases patient disability and mortality. However, the association of low bone mineral density (BMD) with cardiovascular disease (CVD) and all-cause mortality in T2DM patients have not been conclusively established. Methods: Using the National Health and Nutrition Examination Survey (NHANES) to obtain a nationally representative sample of the US population, we sought to determine the independent and incremental value of low BMD, particularly in patients with osteoporosis in assessing all-cause and CVD mortality in adults with T2DM. Results: We demonstrated that increased BMD was significantly related to decreased mortality from all-causes and CVDs among US adults with T2DM. In addition, we found that, after multivariate adjustment, osteoporosis and osteopenia were independently associated with an increased risk of all-cause and CVD mortality in T2DM patients at long-term follow-up. Conclusions: The clinical diagnosis of osteopenia or osteoporosis in adults with T2DM provides independent prognostic value for CVD and all-cause mortality. |
| format | Article |
| id | doaj-art-7d0b2f37ce1e46e08bb68ee0272f00eb |
| institution | DOAJ |
| issn | 1530-6550 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-7d0b2f37ce1e46e08bb68ee0272f00eb2025-08-20T02:51:15ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-12-01251243410.31083/j.rcm2512434S1530-6550(24)01544-8Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014Haipeng Li0Baolong Wang1Dongshuo Xu2Jialu Zhang3Changhui Wang4Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, ChinaDepartment of Cardiology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, ChinaBackground: With ageing and lifestyle changes, the coexistence of osteoporosis and type 2 diabetes (T2DM) is becoming more common, which greatly increases patient disability and mortality. However, the association of low bone mineral density (BMD) with cardiovascular disease (CVD) and all-cause mortality in T2DM patients have not been conclusively established. Methods: Using the National Health and Nutrition Examination Survey (NHANES) to obtain a nationally representative sample of the US population, we sought to determine the independent and incremental value of low BMD, particularly in patients with osteoporosis in assessing all-cause and CVD mortality in adults with T2DM. Results: We demonstrated that increased BMD was significantly related to decreased mortality from all-causes and CVDs among US adults with T2DM. In addition, we found that, after multivariate adjustment, osteoporosis and osteopenia were independently associated with an increased risk of all-cause and CVD mortality in T2DM patients at long-term follow-up. Conclusions: The clinical diagnosis of osteopenia or osteoporosis in adults with T2DM provides independent prognostic value for CVD and all-cause mortality.https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512434bone mineral densityosteoporosistype 2 diabetescardiovascular mortalityall-cause mortalitynhanes database |
| spellingShingle | Haipeng Li Baolong Wang Dongshuo Xu Jialu Zhang Changhui Wang Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 Reviews in Cardiovascular Medicine bone mineral density osteoporosis type 2 diabetes cardiovascular mortality all-cause mortality nhanes database |
| title | Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 |
| title_full | Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 |
| title_fullStr | Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 |
| title_full_unstemmed | Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 |
| title_short | Bone Mineral Density is Negatively Associated with Risk of All-Cause and Cardiovascular Mortality among Adults with Type 2 Diabetes Mellitus: A Cross-sectional Study of the NHANES 2005–2010, 2013–2014 |
| title_sort | bone mineral density is negatively associated with risk of all cause and cardiovascular mortality among adults with type 2 diabetes mellitus a cross sectional study of the nhanes 2005 2010 2013 2014 |
| topic | bone mineral density osteoporosis type 2 diabetes cardiovascular mortality all-cause mortality nhanes database |
| url | https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512434 |
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