HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges
In this literature review, methods for the detection of breast cancer biomarkers and the operation of electrochemical sensors are considered. The work of sensors in the determination of breast cancer biomarkers was systematized, a comparative table with other methods was compiled, as was a classific...
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MDPI AG
2025-03-01
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| Series: | Biosensors |
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| author | Leila Kudreyeva Fatima Kanysh Aliya Sarsenbayeva Moldir Abu Duisek Kamysbayev Kamilya Kedelbayeva |
| author_facet | Leila Kudreyeva Fatima Kanysh Aliya Sarsenbayeva Moldir Abu Duisek Kamysbayev Kamilya Kedelbayeva |
| author_sort | Leila Kudreyeva |
| collection | DOAJ |
| description | In this literature review, methods for the detection of breast cancer biomarkers and the operation of electrochemical sensors are considered. The work of sensors in the determination of breast cancer biomarkers was systematized, a comparative table with other methods was compiled, as was a classification of sensors depending on their intended use. The various traditional methods for the diagnosis of breast cancer biomarkers are described, including mammography, ultrasound, magnetic resonance imaging, positron emission computed tomography, computed tomography, single-photon emission computed tomography, and biopsy, and their advantages and disadvantages are presented. Key sensor parameters for the detection of breast cancer biomarkers are compared, such as the detection limit, linear detection range, response time, sensitivity, and other characteristics depending on the analyte being analyzed. Based on the reviewed scientific papers, the significance of electrochemical sensors in detecting the biomarkers of breast cancer is demonstrated. The types of tumor biomarkers identified by biosensors were analyzed, with a particular focus on HER2. Studies on HER2 detection using electrochemical methods are compared and systematized, and the features of electrochemical biosensors for determining this biomarker are characterized. Possible interfering agents affecting the accuracy of HER2 determination under experimental conditions are considered, their mechanisms of action are analyzed, and ways to eliminate them are proposed. This report provides a summary of the current aspects of scientific research on electrochemical sensors for the detection of breast cancer biomarkers. The development of electrochemical biosensors opens up new prospects for the early diagnosis and prognosis of breast cancer treatment. |
| format | Article |
| id | doaj-art-7d0b03f502074511a8f77e7aa95c847a |
| institution | DOAJ |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-7d0b03f502074511a8f77e7aa95c847a2025-08-20T03:14:20ZengMDPI AGBiosensors2079-63742025-03-0115421010.3390/bios15040210HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and ChallengesLeila Kudreyeva0Fatima Kanysh1Aliya Sarsenbayeva2Moldir Abu3Duisek Kamysbayev4Kamilya Kedelbayeva5Department of Analytical Chemistry, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Analytical Chemistry, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Analytical Chemistry, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Analytical Chemistry, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Analytical Chemistry, Colloidal Chemistry and Technology of Rare Elements, Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, KazakhstanDepartment of Cardiology Asfendiyarov, Kazakh National Medical University, Almaty 050012, KazakhstanIn this literature review, methods for the detection of breast cancer biomarkers and the operation of electrochemical sensors are considered. The work of sensors in the determination of breast cancer biomarkers was systematized, a comparative table with other methods was compiled, as was a classification of sensors depending on their intended use. The various traditional methods for the diagnosis of breast cancer biomarkers are described, including mammography, ultrasound, magnetic resonance imaging, positron emission computed tomography, computed tomography, single-photon emission computed tomography, and biopsy, and their advantages and disadvantages are presented. Key sensor parameters for the detection of breast cancer biomarkers are compared, such as the detection limit, linear detection range, response time, sensitivity, and other characteristics depending on the analyte being analyzed. Based on the reviewed scientific papers, the significance of electrochemical sensors in detecting the biomarkers of breast cancer is demonstrated. The types of tumor biomarkers identified by biosensors were analyzed, with a particular focus on HER2. Studies on HER2 detection using electrochemical methods are compared and systematized, and the features of electrochemical biosensors for determining this biomarker are characterized. Possible interfering agents affecting the accuracy of HER2 determination under experimental conditions are considered, their mechanisms of action are analyzed, and ways to eliminate them are proposed. This report provides a summary of the current aspects of scientific research on electrochemical sensors for the detection of breast cancer biomarkers. The development of electrochemical biosensors opens up new prospects for the early diagnosis and prognosis of breast cancer treatment.https://www.mdpi.com/2079-6374/15/4/210breast cancerbiomarkerbiosensorelectrochemical sensorinterfering agent |
| spellingShingle | Leila Kudreyeva Fatima Kanysh Aliya Sarsenbayeva Moldir Abu Duisek Kamysbayev Kamilya Kedelbayeva HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges Biosensors breast cancer biomarker biosensor electrochemical sensor interfering agent |
| title | HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges |
| title_full | HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges |
| title_fullStr | HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges |
| title_full_unstemmed | HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges |
| title_short | HER-2-Targeted Electrochemical Sensors for Breast Cancer Diagnosis: Basic Principles, Recent Advancements, and Challenges |
| title_sort | her 2 targeted electrochemical sensors for breast cancer diagnosis basic principles recent advancements and challenges |
| topic | breast cancer biomarker biosensor electrochemical sensor interfering agent |
| url | https://www.mdpi.com/2079-6374/15/4/210 |
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