The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress
Klotho, an anti-aging protein, has been extensively studied in systemic conditions such as chronic kidney disease and cardiovascular disorders. In recent years, its pivotal protective role and clinical significance in various oral and maxillofacial diseases have been increasingly demonstrated. It ha...
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2025-04-01
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| author | Shiqi Lin Bozhao Wang Jian Li |
| author_facet | Shiqi Lin Bozhao Wang Jian Li |
| author_sort | Shiqi Lin |
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| description | Klotho, an anti-aging protein, has been extensively studied in systemic conditions such as chronic kidney disease and cardiovascular disorders. In recent years, its pivotal protective role and clinical significance in various oral and maxillofacial diseases have been increasingly demonstrated. It has been demonstrated that Klotho regulates oxidative stress, apoptosis, inflammation, and fibrosis via multiple molecular signaling pathways, including Nrf2, NF-κB, PI3K/Akt/FoxO1, insulin/IGF-1, FGF/FGFR, and Wnt/β-catenin. Consequently, these regulatory effects have been observed in conditions such as periodontitis, oral squamous cell carcinoma, malignant salivary gland tumors, oral submucous fibrosis, etc. Moreover, the decreased expression or dysfunctional activity of Klotho is frequently associated with the onset and progression of these diseases. This study provides a comprehensive review of the underlying mechanisms and recent advances in Klotho research within the realm of oral and maxillofacial diseases, offering novel perspectives for future basic and clinical investigations. |
| format | Article |
| id | doaj-art-7d088e805e5b4b5f9efa0377bb3929af |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-7d088e805e5b4b5f9efa0377bb3929af2025-08-20T03:47:48ZengMDPI AGBiomolecules2218-273X2025-04-0115562410.3390/biom15050624The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research ProgressShiqi Lin0Bozhao Wang1Jian Li2School of Medicine, Xiamen University, Xiamen 361102, ChinaSchool of Medicine, Xiamen University, Xiamen 361102, ChinaSchool of Medicine, Xiamen University, Xiamen 361102, ChinaKlotho, an anti-aging protein, has been extensively studied in systemic conditions such as chronic kidney disease and cardiovascular disorders. In recent years, its pivotal protective role and clinical significance in various oral and maxillofacial diseases have been increasingly demonstrated. It has been demonstrated that Klotho regulates oxidative stress, apoptosis, inflammation, and fibrosis via multiple molecular signaling pathways, including Nrf2, NF-κB, PI3K/Akt/FoxO1, insulin/IGF-1, FGF/FGFR, and Wnt/β-catenin. Consequently, these regulatory effects have been observed in conditions such as periodontitis, oral squamous cell carcinoma, malignant salivary gland tumors, oral submucous fibrosis, etc. Moreover, the decreased expression or dysfunctional activity of Klotho is frequently associated with the onset and progression of these diseases. This study provides a comprehensive review of the underlying mechanisms and recent advances in Klotho research within the realm of oral and maxillofacial diseases, offering novel perspectives for future basic and clinical investigations.https://www.mdpi.com/2218-273X/15/5/624Klothooral and maxillofacial diseasesoxidative stressinflammationapoptosisanti-aging |
| spellingShingle | Shiqi Lin Bozhao Wang Jian Li The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress Biomolecules Klotho oral and maxillofacial diseases oxidative stress inflammation apoptosis anti-aging |
| title | The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress |
| title_full | The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress |
| title_fullStr | The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress |
| title_full_unstemmed | The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress |
| title_short | The Role of Klotho in Oral and Maxillofacial Diseases: Mechanisms and Research Progress |
| title_sort | role of klotho in oral and maxillofacial diseases mechanisms and research progress |
| topic | Klotho oral and maxillofacial diseases oxidative stress inflammation apoptosis anti-aging |
| url | https://www.mdpi.com/2218-273X/15/5/624 |
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