Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases
It is known that the dysfunction of the endothelium has crucial role in many pathological conditions and underlines adverse cardiovascular events. The aim of our study was to determine biologically active substances in the blood that affect endothelial function and homocysteine level in adolescen...
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| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2024-03-01
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| Series: | Сучасні медичні технології |
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| Online Access: | https://medtech.mphu.edu.ua/article/view/298488/292786 |
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| author | T. O. Holovko L. F. Bohmat N. S. Shevchenko Yu. V. Volkova L. L. Sukhova O. S. Pavlova |
| author_facet | T. O. Holovko L. F. Bohmat N. S. Shevchenko Yu. V. Volkova L. L. Sukhova O. S. Pavlova |
| author_sort | T. O. Holovko |
| collection | DOAJ |
| description | It is known that the dysfunction of the endothelium has crucial role in many pathological conditions and underlines adverse cardiovascular events.
The aim of our study was to determine biologically active substances in the blood that affect endothelial function and homocysteine level in adolescents with rheumatic diseases.
Materials and methods. We examined 68 patients with rheumatic diseases, among them 25 patients with systemic lupus erythematosus (SLE) and 43 patients with juvenile idiopathic arthritis (JIA). Obtained results were compared with similar indicators of peers from the control group. All patients received basic therapy for 12 or more months at the time of examination. Biologically active substances (Homocysteine (Hcy), vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP)) were studied by enzyme-linked immunosorbent assay, brain natriuretic peptide (NT-proBNP) by competitive immunoassay, and angiotensin-converting enzyme (ACE) by turbidimetric FAPGG kinetics method.
Results. Patients with rheumatic diseases had a significantly higher level of BNP (p < 0.01). These changes were most significant in patients with SLE. The level of Hcy did not differ from the similar indicator of the control group, but in patients with SLE it was significantly higher (p < 0.01) than in patients with JIA.
Conclusions. In patients with rheumatic diseases, biologically active substances level affecting the endothelium function depends on the disease. Biologically active substances affecting the function of the endothelium were within normal values. Thus, in children with SLE compared with JIA children, an increase in Hcy and NT-proBNP, and a decrease in ACE and hs-CRP protein were found. In children with JIA, normal levels of Hcy and ACE are accompanied by an increase in NT-proBNP and hs-CRP. In adolescents aged 10–18 years with SLE and JIA, multidirectional changes in biologically active substances and homocysteine, affecting the endothelial function of blood vessels were found. |
| format | Article |
| id | doaj-art-7d04038e197848239590b5ad40473c6c |
| institution | Kabale University |
| issn | 2072-9367 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Сучасні медичні технології |
| spelling | doaj-art-7d04038e197848239590b5ad40473c6c2025-02-03T11:47:00ZengZaporizhzhia State Medical and Pharmaceutical UniversityСучасні медичні технології2072-93672024-03-011614045https://doi.org/10.14739/mmt.2024.1.298488Endothelial factors and blood homocysteine level in adolescents with rheumatic diseasesT. O. Holovko0https://orcid.org/0000-0003-3815-7874L. F. Bohmat1https://orcid.org/0000-0001-5144-3686N. S. Shevchenko2https://orcid.org/0000-0003-4407-6050Yu. V. Volkova3https://orcid.org/0000-0001-9625-941XL. L. Sukhova4https://orcid.org/0000-0001-7248-5754O. S. Pavlova5https://orcid.org/0000-0003-2365-4827V. N. Karazin Kharkiv National University, UkraineState Institution “Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine”, KharkivV. N. Karazin Kharkiv National University, UkraineState Institution “Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine”, KharkivState Institution “Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine”, KharkivV. N. Karazin Kharkiv National University, UkraineIt is known that the dysfunction of the endothelium has crucial role in many pathological conditions and underlines adverse cardiovascular events. The aim of our study was to determine biologically active substances in the blood that affect endothelial function and homocysteine level in adolescents with rheumatic diseases. Materials and methods. We examined 68 patients with rheumatic diseases, among them 25 patients with systemic lupus erythematosus (SLE) and 43 patients with juvenile idiopathic arthritis (JIA). Obtained results were compared with similar indicators of peers from the control group. All patients received basic therapy for 12 or more months at the time of examination. Biologically active substances (Homocysteine (Hcy), vascular endothelial growth factor (VEGF), high-sensitivity C-reactive protein (hs-CRP)) were studied by enzyme-linked immunosorbent assay, brain natriuretic peptide (NT-proBNP) by competitive immunoassay, and angiotensin-converting enzyme (ACE) by turbidimetric FAPGG kinetics method. Results. Patients with rheumatic diseases had a significantly higher level of BNP (p < 0.01). These changes were most significant in patients with SLE. The level of Hcy did not differ from the similar indicator of the control group, but in patients with SLE it was significantly higher (p < 0.01) than in patients with JIA. Conclusions. In patients with rheumatic diseases, biologically active substances level affecting the endothelium function depends on the disease. Biologically active substances affecting the function of the endothelium were within normal values. Thus, in children with SLE compared with JIA children, an increase in Hcy and NT-proBNP, and a decrease in ACE and hs-CRP protein were found. In children with JIA, normal levels of Hcy and ACE are accompanied by an increase in NT-proBNP and hs-CRP. In adolescents aged 10–18 years with SLE and JIA, multidirectional changes in biologically active substances and homocysteine, affecting the endothelial function of blood vessels were found.https://medtech.mphu.edu.ua/article/view/298488/292786rheumatic diseasesvascular endothelium functionhomocysteinevascular endothelial growth factorbrain natriuretic peptideangiotensin-converting enzymeadolescents |
| spellingShingle | T. O. Holovko L. F. Bohmat N. S. Shevchenko Yu. V. Volkova L. L. Sukhova O. S. Pavlova Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases Сучасні медичні технології rheumatic diseases vascular endothelium function homocysteine vascular endothelial growth factor brain natriuretic peptide angiotensin-converting enzyme adolescents |
| title | Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| title_full | Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| title_fullStr | Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| title_full_unstemmed | Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| title_short | Endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| title_sort | endothelial factors and blood homocysteine level in adolescents with rheumatic diseases |
| topic | rheumatic diseases vascular endothelium function homocysteine vascular endothelial growth factor brain natriuretic peptide angiotensin-converting enzyme adolescents |
| url | https://medtech.mphu.edu.ua/article/view/298488/292786 |
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