Inositol Treatment and ART Outcomes in Women with PCOS
Polycystic ovary syndrome (PCOS) affects 5–10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology...
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/1979654 |
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| author | Deepika Garg Reshef Tal |
| author_facet | Deepika Garg Reshef Tal |
| author_sort | Deepika Garg |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) affects 5–10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology is still unknown but is believed to be multifactorial. Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Administration of inositol in PCOS has been shown to improve not only the metabolic and hormonal parameters but also ovarian function and the response to assisted-reproductive technology (ART). Accumulating evidence suggests that it is also capable of improving folliculogenesis and embryo quality and increasing the mature oocyte yield following ovarian stimulation for ART in women with PCOS. In the current review, we collate the evidence and summarize our current knowledge on ovarian stimulation and ART outcomes following inositol treatment in women with PCOS undergoing in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). |
| format | Article |
| id | doaj-art-7d01bb27f6124beb8cd93ccb03aa4f3e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7d01bb27f6124beb8cd93ccb03aa4f3e2025-08-20T03:35:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/19796541979654Inositol Treatment and ART Outcomes in Women with PCOSDeepika Garg0Reshef Tal1Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, USADivision of Reproductive Endocrinology & Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USAPolycystic ovary syndrome (PCOS) affects 5–10% of women in reproductive age and is characterized by oligo/amenorrhea, androgen excess, insulin resistance, and typical polycystic ovarian morphology. It is the most common cause of infertility secondary to ovulatory dysfunction. The underlying etiology is still unknown but is believed to be multifactorial. Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Administration of inositol in PCOS has been shown to improve not only the metabolic and hormonal parameters but also ovarian function and the response to assisted-reproductive technology (ART). Accumulating evidence suggests that it is also capable of improving folliculogenesis and embryo quality and increasing the mature oocyte yield following ovarian stimulation for ART in women with PCOS. In the current review, we collate the evidence and summarize our current knowledge on ovarian stimulation and ART outcomes following inositol treatment in women with PCOS undergoing in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI).http://dx.doi.org/10.1155/2016/1979654 |
| spellingShingle | Deepika Garg Reshef Tal Inositol Treatment and ART Outcomes in Women with PCOS International Journal of Endocrinology |
| title | Inositol Treatment and ART Outcomes in Women with PCOS |
| title_full | Inositol Treatment and ART Outcomes in Women with PCOS |
| title_fullStr | Inositol Treatment and ART Outcomes in Women with PCOS |
| title_full_unstemmed | Inositol Treatment and ART Outcomes in Women with PCOS |
| title_short | Inositol Treatment and ART Outcomes in Women with PCOS |
| title_sort | inositol treatment and art outcomes in women with pcos |
| url | http://dx.doi.org/10.1155/2016/1979654 |
| work_keys_str_mv | AT deepikagarg inositoltreatmentandartoutcomesinwomenwithpcos AT resheftal inositoltreatmentandartoutcomesinwomenwithpcos |