Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease
Introduction The possibilities of medical visualization of changes in the articular cartilage and subchondral bone in wrist osteoarthritis are limited. There are few studies devoted to its histological manifestations. The purpose f the work was to determine the relationships between histological f...
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Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
2025-08-01
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| Series: | Гений oртопедии |
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| author | Nathalia A. Shchudlo Tatyana A. Stupina Shyngys K. Kuttygul |
| author_facet | Nathalia A. Shchudlo Tatyana A. Stupina Shyngys K. Kuttygul |
| author_sort | Nathalia A. Shchudlo |
| collection | DOAJ |
| description | Introduction The possibilities of medical visualization of changes in the articular cartilage and subchondral
bone in wrist osteoarthritis are limited. There are few studies devoted to its histological manifestations.
The purpose f the work was to determine the relationships between histological features of wrist osteoarthritis
and the duration and stage of SLAC / SNAC syndrome.
Material and methods The surgical material of 12 patients who underwent resection of the proximal row
of wrist bones or removal of the scaphoid bone and intercarpal arthrodesis was studied. In nine patients,
the duration of the disease was shorter than four years and in three it was from 10 to 22 years. Stage I
SLAC / SNAC syndrome was detected in two patients, stage II — in six, stage III — in four. Cartilage changes were
assessed using the international OARSI scale, the prevalence of subchondral bone necrosis was determined
semi-quantitatively (from 0 to 3 points) in 3–10 fields of microscopic views of the from each patient.
Results The OARSI score varied from 1–2 to 5 points if the duration of the disease was shorter than four years
and from 3–4 to 4–5 points if it continued from 10 to 22 years. The osteonecrosis score in the compared
subgroups was 3 (2÷3)(0–3) and 3 (2÷3)(2–3), p = 0.11. In SLAC / SNAC stage I, the OARSI score variability
ranges from 1–2 to 4, in stage II — from 2 to 4–5, in stage III — from 3–4 to 5. The osteonecrosis score
in the compared subgroups was 2 (1÷2)(1–3), 3 (2÷3)(1–3), and 3 (2÷3)(0–3) (P1-2 = 0.03; P2-3 = 0.62; P1-3 = 0.02).
Discussion The SLAC / SNAC syndrome can be of two types, progressive and stagnant. In the second type,
the disease is asymptomatic for a long time. Regardless of the cause of SLAC / SNAC syndrome, all patients
with wrist osteoarthritis experience irreversible osteonecrosis of the subchondral bone and bone marrow,
which probably reflects the degree of acute or chronic damage to the vessels that feed the bone.
Conclusion With a general tendency for greater degenerative changes in the articular cartilage at a higher
stage of SLAC / SNAC syndrome, their histological manifestations vary between individuals at each stage.
Osteonecrosis of the subchondral bone is more common in SLAC / SNAC stages II–III than in stage I. |
| format | Article |
| id | doaj-art-7d01019541f34bb494116be83d372a74 |
| institution | Kabale University |
| issn | 1028-4427 2542-131X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics |
| record_format | Article |
| series | Гений oртопедии |
| spelling | doaj-art-7d01019541f34bb494116be83d372a742025-08-20T06:12:15ZengRussian Ilizarov Scientific Center for Restorative Traumatology and OrthopaedicsГений oртопедии1028-44272542-131X2025-08-0131444445110.18019/1028-4427-2025-31-4-444-451Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the diseaseNathalia A. Shchudlo0https://orcid.org/0000-0001-9914-8563Tatyana A. Stupina1https://orcid.org/0000-0003-3434-0372Shyngys K. Kuttygul2https://orcid.org/0009-0009-1072-468X Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation Ilizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian FederationIlizarov National Medical Research Centre for Traumatology and Orthopedics, Kurgan, Russian Federation Introduction The possibilities of medical visualization of changes in the articular cartilage and subchondral bone in wrist osteoarthritis are limited. There are few studies devoted to its histological manifestations. The purpose f the work was to determine the relationships between histological features of wrist osteoarthritis and the duration and stage of SLAC / SNAC syndrome. Material and methods The surgical material of 12 patients who underwent resection of the proximal row of wrist bones or removal of the scaphoid bone and intercarpal arthrodesis was studied. In nine patients, the duration of the disease was shorter than four years and in three it was from 10 to 22 years. Stage I SLAC / SNAC syndrome was detected in two patients, stage II — in six, stage III — in four. Cartilage changes were assessed using the international OARSI scale, the prevalence of subchondral bone necrosis was determined semi-quantitatively (from 0 to 3 points) in 3–10 fields of microscopic views of the from each patient. Results The OARSI score varied from 1–2 to 5 points if the duration of the disease was shorter than four years and from 3–4 to 4–5 points if it continued from 10 to 22 years. The osteonecrosis score in the compared subgroups was 3 (2÷3)(0–3) and 3 (2÷3)(2–3), p = 0.11. In SLAC / SNAC stage I, the OARSI score variability ranges from 1–2 to 4, in stage II — from 2 to 4–5, in stage III — from 3–4 to 5. The osteonecrosis score in the compared subgroups was 2 (1÷2)(1–3), 3 (2÷3)(1–3), and 3 (2÷3)(0–3) (P1-2 = 0.03; P2-3 = 0.62; P1-3 = 0.02). Discussion The SLAC / SNAC syndrome can be of two types, progressive and stagnant. In the second type, the disease is asymptomatic for a long time. Regardless of the cause of SLAC / SNAC syndrome, all patients with wrist osteoarthritis experience irreversible osteonecrosis of the subchondral bone and bone marrow, which probably reflects the degree of acute or chronic damage to the vessels that feed the bone. Conclusion With a general tendency for greater degenerative changes in the articular cartilage at a higher stage of SLAC / SNAC syndrome, their histological manifestations vary between individuals at each stage. Osteonecrosis of the subchondral bone is more common in SLAC / SNAC stages II–III than in stage I.slac / snac syndromewrist osteoarthritisarticular cartilagesubchondral bonehistology |
| spellingShingle | Nathalia A. Shchudlo Tatyana A. Stupina Shyngys K. Kuttygul Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease Гений oртопедии slac / snac syndrome wrist osteoarthritis articular cartilage subchondral bone histology |
| title | Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| title_full | Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| title_fullStr | Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| title_full_unstemmed | Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| title_short | Histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| title_sort | histological manifestations of wrist osteoarthritis and their dependence on the duration and severity of the disease |
| topic | slac / snac syndrome wrist osteoarthritis articular cartilage subchondral bone histology |
| work_keys_str_mv | AT nathaliaashchudlo histologicalmanifestationsofwristosteoarthritisandtheirdependenceonthedurationandseverityofthedisease AT tatyanaastupina histologicalmanifestationsofwristosteoarthritisandtheirdependenceonthedurationandseverityofthedisease AT shyngyskkuttygul histologicalmanifestationsofwristosteoarthritisandtheirdependenceonthedurationandseverityofthedisease |