Immune-related hub genes and their role in psoriasis pathogenesis
Abstract Psoriasis is a prevalent inflammatory skin disorder with immune-related mechanisms that remain incompletely understood. To elucidate the immune landscape of psoriasis, we analyzed expression profiles to identify 115 psoriasis susceptibility genes (PSGs) and subsequently pinpointing eight im...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-02822-1 |
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| author | Tingting Yin Tingting Zhang Lei Ma |
| author_facet | Tingting Yin Tingting Zhang Lei Ma |
| author_sort | Tingting Yin |
| collection | DOAJ |
| description | Abstract Psoriasis is a prevalent inflammatory skin disorder with immune-related mechanisms that remain incompletely understood. To elucidate the immune landscape of psoriasis, we analyzed expression profiles to identify 115 psoriasis susceptibility genes (PSGs) and subsequently pinpointing eight immune-related hub genes (IRHGs). A predictive model incorporating these IRHGs demonstrated promising prognostic potential for psoriasis. Additionally, extensive intercellular communication was observed among keratinocytes, dendritic cells, monocytes, and T cells. The cellular differentiation trajectory revealed a complex interplay among various cell types and states, highlighting genes such as CXCL8, CCL2, STAT3, and STAT1 emerging as closely associated with the cellular composition and functional status within the psoriatic immune microenvironment. The present study may shed light on the understanding of the immunopathological dynamics of psoriasis and the development of novel therapeutic strategies and biomarkers for this multifaceted skin disorder. |
| format | Article |
| id | doaj-art-7cffeac574a74feca6347c3e64998bd1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7cffeac574a74feca6347c3e64998bd12025-08-20T03:48:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111810.1038/s41598-025-02822-1Immune-related hub genes and their role in psoriasis pathogenesisTingting Yin0Tingting Zhang1Lei Ma2College of Life Science, Shihezi UniversityCollege of Life Science, Shihezi UniversityCollege of Life Science, Shihezi UniversityAbstract Psoriasis is a prevalent inflammatory skin disorder with immune-related mechanisms that remain incompletely understood. To elucidate the immune landscape of psoriasis, we analyzed expression profiles to identify 115 psoriasis susceptibility genes (PSGs) and subsequently pinpointing eight immune-related hub genes (IRHGs). A predictive model incorporating these IRHGs demonstrated promising prognostic potential for psoriasis. Additionally, extensive intercellular communication was observed among keratinocytes, dendritic cells, monocytes, and T cells. The cellular differentiation trajectory revealed a complex interplay among various cell types and states, highlighting genes such as CXCL8, CCL2, STAT3, and STAT1 emerging as closely associated with the cellular composition and functional status within the psoriatic immune microenvironment. The present study may shed light on the understanding of the immunopathological dynamics of psoriasis and the development of novel therapeutic strategies and biomarkers for this multifaceted skin disorder.https://doi.org/10.1038/s41598-025-02822-1PsoriasisBulk RNA-SeqscRNA-SeqPrognostic modelImmune microenvironment |
| spellingShingle | Tingting Yin Tingting Zhang Lei Ma Immune-related hub genes and their role in psoriasis pathogenesis Scientific Reports Psoriasis Bulk RNA-Seq scRNA-Seq Prognostic model Immune microenvironment |
| title | Immune-related hub genes and their role in psoriasis pathogenesis |
| title_full | Immune-related hub genes and their role in psoriasis pathogenesis |
| title_fullStr | Immune-related hub genes and their role in psoriasis pathogenesis |
| title_full_unstemmed | Immune-related hub genes and their role in psoriasis pathogenesis |
| title_short | Immune-related hub genes and their role in psoriasis pathogenesis |
| title_sort | immune related hub genes and their role in psoriasis pathogenesis |
| topic | Psoriasis Bulk RNA-Seq scRNA-Seq Prognostic model Immune microenvironment |
| url | https://doi.org/10.1038/s41598-025-02822-1 |
| work_keys_str_mv | AT tingtingyin immunerelatedhubgenesandtheirroleinpsoriasispathogenesis AT tingtingzhang immunerelatedhubgenesandtheirroleinpsoriasispathogenesis AT leima immunerelatedhubgenesandtheirroleinpsoriasispathogenesis |