Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk
ABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity,...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.71030 |
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| author | Bo‐Tao Zhang Mao Guo Liu‐Rui Yang Yang Zeng Jun Jiang |
| author_facet | Bo‐Tao Zhang Mao Guo Liu‐Rui Yang Yang Zeng Jun Jiang |
| author_sort | Bo‐Tao Zhang |
| collection | DOAJ |
| description | ABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity, inflammation, and oxidative stress to thyroid cancer. Results Chronic inflammation, a well‐known risk factor for cancer progression, is a hallmark characteristic of obesity. Multiple mechanisms may mediate the association between thyroid cancer and obesity. As a crucial endocrine organ, adipose tissue regulates tumor behavior, inflammation, and the tumor microenvironment through adipokines, including leptin, adiponectin, as well as chemokines. Excessive fat accumulation leads to an increase in pro‐inflammatory factors, which in turn result in systemic inflammation that can further influence tumor growth and development. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and their elimination by antioxidants, can potentially result in cellular damage and destruction. With the accumulation of ROS, it participates in numerous diseases, such as cancer and inflammation. The inflammatory condition of the thyroid gland serves as a classical source of ROS, which may, in turn, promote the development of thyroid tumors. Conclusion While various mechanisms may elucidate the relationship between inflammation, oxidative stress, and the risk of thyroid cancer, the interplay among these factors is intricate and cannot be solely attributed to a singular pathway. This review provides further insight into a strategy for the prevention and treatment of thyroid cancer, highlighting the significance of combinatorial approaches that target multiple pathways in antitumor therapy. |
| format | Article |
| id | doaj-art-7cfe84fdfd5643a5a921446bd24f4f8d |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-7cfe84fdfd5643a5a921446bd24f4f8d2025-08-20T02:54:53ZengWileyCancer Medicine2045-76342025-07-011413n/an/a10.1002/cam4.71030Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer RiskBo‐Tao Zhang0Mao Guo1Liu‐Rui Yang2Yang Zeng3Jun Jiang4Department of Pain Management Luzhou People's Hospital Luzhou ChinaDepartment of Pain Management Luzhou People's Hospital Luzhou ChinaMedical Insurance and Price Management Department Luzhou People's Hospital Luzhou ChinaDepartment of Orthodontics The Affiliated Stomatology Hospital of Southwest Medical University Luzhou ChinaDepartment of General Surgery (Thyroid Surgery) The Affiliated Hospital of Southwest Medical University Luzhou ChinaABSTRACT Aim To investigate the mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk. Methods We have systematically searched the PubMed and Web of Science databases to perform a comprehensive analysis of the pathogenic mechanisms that link obesity, inflammation, and oxidative stress to thyroid cancer. Results Chronic inflammation, a well‐known risk factor for cancer progression, is a hallmark characteristic of obesity. Multiple mechanisms may mediate the association between thyroid cancer and obesity. As a crucial endocrine organ, adipose tissue regulates tumor behavior, inflammation, and the tumor microenvironment through adipokines, including leptin, adiponectin, as well as chemokines. Excessive fat accumulation leads to an increase in pro‐inflammatory factors, which in turn result in systemic inflammation that can further influence tumor growth and development. Oxidative stress, characterized by an imbalance between the production of reactive oxygen species (ROS) and their elimination by antioxidants, can potentially result in cellular damage and destruction. With the accumulation of ROS, it participates in numerous diseases, such as cancer and inflammation. The inflammatory condition of the thyroid gland serves as a classical source of ROS, which may, in turn, promote the development of thyroid tumors. Conclusion While various mechanisms may elucidate the relationship between inflammation, oxidative stress, and the risk of thyroid cancer, the interplay among these factors is intricate and cannot be solely attributed to a singular pathway. This review provides further insight into a strategy for the prevention and treatment of thyroid cancer, highlighting the significance of combinatorial approaches that target multiple pathways in antitumor therapy.https://doi.org/10.1002/cam4.71030adipocytokineschronic inflammationobesityoxidative stressreactive oxygen speciesthyroid cancer |
| spellingShingle | Bo‐Tao Zhang Mao Guo Liu‐Rui Yang Yang Zeng Jun Jiang Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk Cancer Medicine adipocytokines chronic inflammation obesity oxidative stress reactive oxygen species thyroid cancer |
| title | Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk |
| title_full | Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk |
| title_fullStr | Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk |
| title_full_unstemmed | Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk |
| title_short | Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk |
| title_sort | mechanistic aspects of inflammation and oxidative stress and their association with thyroid cancer risk |
| topic | adipocytokines chronic inflammation obesity oxidative stress reactive oxygen species thyroid cancer |
| url | https://doi.org/10.1002/cam4.71030 |
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