A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects
Abstract Metallic scaffolds have shown promise in regenerating critical bone defects. However, limitations persist in achieving a modulus below 100 MPa due to insufficient strength. Consequently, the osteogenic impact of lower modulus and greater bone tissue strain ( > 1%) remains unclear. Here,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57609-9 |
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| author | Yu Qin Zehao Jing Da Zou Youhao Wang Hongtao Yang Kai Chen Weishi Li Peng Wen Yufeng Zheng |
| author_facet | Yu Qin Zehao Jing Da Zou Youhao Wang Hongtao Yang Kai Chen Weishi Li Peng Wen Yufeng Zheng |
| author_sort | Yu Qin |
| collection | DOAJ |
| description | Abstract Metallic scaffolds have shown promise in regenerating critical bone defects. However, limitations persist in achieving a modulus below 100 MPa due to insufficient strength. Consequently, the osteogenic impact of lower modulus and greater bone tissue strain ( > 1%) remains unclear. Here, we introduce a metamaterial scaffold that decouples strength and modulus through two-stage deformation. The scaffold facilitates an effective modulus of only 13 MPa, ensuring adaptability during bone regeneration. Followed by a stiff stage, it provides the necessary strength for load-bearing requirements. In vivo, the scaffold induces > 2% callus strain, upregulating calcium channels and HIF-1α to enhance osteogenesis and angiogenesis. 4-week histomorphology reveals a 44% and 498% increase in new bone fraction versus classic scaffolds with 500 MPa and 13 MPa modulus, respectively. This design transcends traditional modulus-matching paradigms, prioritizing bone tissue strain requirements. Its tunable mechanical properties also present promising implications for advancing osteogenesis mechanisms and addressing clinical challenges. |
| format | Article |
| id | doaj-art-7cfe365701a442a1a1df1bb485a74f8f |
| institution | DOAJ |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-7cfe365701a442a1a1df1bb485a74f8f2025-08-20T02:59:57ZengNature PortfolioNature Communications2041-17232025-03-0116111210.1038/s41467-025-57609-9A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defectsYu Qin0Zehao Jing1Da Zou2Youhao Wang3Hongtao Yang4Kai Chen5Weishi Li6Peng Wen7Yufeng Zheng8School of Materials Science and Engineering, Peking UniversityDepartment of Orthopedics, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalDepartment of Orthopedics, Peking University Third HospitalSchool of Biological Science and Medical Engineering, Beihang UniversitySchool of Materials Science and Engineering, Peking UniversityDepartment of Orthopedics, Peking University Third HospitalDepartment of Mechanical Engineering, Tsinghua UniversitySchool of Materials Science and Engineering, Peking UniversityAbstract Metallic scaffolds have shown promise in regenerating critical bone defects. However, limitations persist in achieving a modulus below 100 MPa due to insufficient strength. Consequently, the osteogenic impact of lower modulus and greater bone tissue strain ( > 1%) remains unclear. Here, we introduce a metamaterial scaffold that decouples strength and modulus through two-stage deformation. The scaffold facilitates an effective modulus of only 13 MPa, ensuring adaptability during bone regeneration. Followed by a stiff stage, it provides the necessary strength for load-bearing requirements. In vivo, the scaffold induces > 2% callus strain, upregulating calcium channels and HIF-1α to enhance osteogenesis and angiogenesis. 4-week histomorphology reveals a 44% and 498% increase in new bone fraction versus classic scaffolds with 500 MPa and 13 MPa modulus, respectively. This design transcends traditional modulus-matching paradigms, prioritizing bone tissue strain requirements. Its tunable mechanical properties also present promising implications for advancing osteogenesis mechanisms and addressing clinical challenges.https://doi.org/10.1038/s41467-025-57609-9 |
| spellingShingle | Yu Qin Zehao Jing Da Zou Youhao Wang Hongtao Yang Kai Chen Weishi Li Peng Wen Yufeng Zheng A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects Nature Communications |
| title | A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects |
| title_full | A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects |
| title_fullStr | A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects |
| title_full_unstemmed | A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects |
| title_short | A metamaterial scaffold beyond modulus limits: enhanced osteogenesis and angiogenesis of critical bone defects |
| title_sort | metamaterial scaffold beyond modulus limits enhanced osteogenesis and angiogenesis of critical bone defects |
| url | https://doi.org/10.1038/s41467-025-57609-9 |
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