T-ing up the storm: pathogenic cycling lymphocytes in the biology of macrophage activation syndrome

T-ing up the storm: pathogenic cycling lymphocytes in the biology of macrophage activation syndrome

Abstract Background Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are potentially fatal cytokine storm syndromes with clinical features including fever, pancytopenia, hepatosplenomegaly, coagulopathy, and progressive multiorgan system dysfunction. Mechanistically,...

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Bibliographic Details
Main Authors: Michael T. Lam, Connie L. Jiang, Pui Y. Lee
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Pediatric Rheumatology Online Journal
Subjects:
Macrophage activation syndrome
Hemophagocytic lymphohistiocytosis
T lymphocytes
Online Access:https://doi.org/10.1186/s12969-025-01081-8
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