Puberty, sex, and fear extinction retention: A neuroimaging study in youth
Anxiety disorders affect 31.1 % of U.S. adults, with females exhibiting twice the prevalence of males. While sex differences are well-documented, underlying mechanisms remain unclear. Advanced pubertal status is linked to increased anxiety symptoms in females but not males, suggesting puberty contri...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Developmental Cognitive Neuroscience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929325000908 |
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| author | Sneha Bhargava Clara G. Zundel MacKenna Shampine Samantha Ely Carmen Carpenter Jennifer Losiowski Shravya Chanamolu Jovan Jande Reem Tamimi Kamakashi Sharma Emilie O’Mara Alaina M. Jaster Hilary A. Marusak |
| author_facet | Sneha Bhargava Clara G. Zundel MacKenna Shampine Samantha Ely Carmen Carpenter Jennifer Losiowski Shravya Chanamolu Jovan Jande Reem Tamimi Kamakashi Sharma Emilie O’Mara Alaina M. Jaster Hilary A. Marusak |
| author_sort | Sneha Bhargava |
| collection | DOAJ |
| description | Anxiety disorders affect 31.1 % of U.S. adults, with females exhibiting twice the prevalence of males. While sex differences are well-documented, underlying mechanisms remain unclear. Advanced pubertal status is linked to increased anxiety symptoms in females but not males, suggesting puberty contributes to sex differences in fear-based disorders. Deficits in fear extinction and retention are implicated in anxiety, and prior research suggests sex hormones influence extinction retention. This study examined sex assigned at birth (parent-reported) and pubertal status (self-reported) on extinction retention in 101 youth (47.5 % female) using a Pavlovian fear extinction paradigm. Measures included self-reported anxiety symptoms, extinction retention, and neural activation in the amygdala, hippocampus, and anterior cingulate cortex (ACC). |
| format | Article |
| id | doaj-art-7cfca53b53e94ee6aefe061cccb797c8 |
| institution | Kabale University |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-7cfca53b53e94ee6aefe061cccb797c82025-08-20T03:28:43ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-10-017510159510.1016/j.dcn.2025.101595Puberty, sex, and fear extinction retention: A neuroimaging study in youthSneha Bhargava0Clara G. Zundel1MacKenna Shampine2Samantha Ely3Carmen Carpenter4Jennifer Losiowski5Shravya Chanamolu6Jovan Jande7Reem Tamimi8Kamakashi Sharma9Emilie O’Mara10Alaina M. Jaster11Hilary A. Marusak12Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USA; Merrill Palmer Skillman Institute for Child and Family Development Wayne State University, 71 East Ferry Street, Detroit, MI 48202, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USAMichigan State University College of Osteopathic Medicine, 965 Wilson Rd, East Lansing, MI 48824, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USADepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 3901 Chrysler Service Dr, Detroit, MI 48201, USA; Merrill Palmer Skillman Institute for Child and Family Development Wayne State University, 71 East Ferry Street, Detroit, MI 48202, USA; Department of Pharmacology, Wayne State University School of Medicine, 540 E Canfield St, Detroit, MI 48201, USA; Correspondence to: 3901 Chrysler Service Dr., Suite 2B, Detroit, MI 48201, USA.Anxiety disorders affect 31.1 % of U.S. adults, with females exhibiting twice the prevalence of males. While sex differences are well-documented, underlying mechanisms remain unclear. Advanced pubertal status is linked to increased anxiety symptoms in females but not males, suggesting puberty contributes to sex differences in fear-based disorders. Deficits in fear extinction and retention are implicated in anxiety, and prior research suggests sex hormones influence extinction retention. This study examined sex assigned at birth (parent-reported) and pubertal status (self-reported) on extinction retention in 101 youth (47.5 % female) using a Pavlovian fear extinction paradigm. Measures included self-reported anxiety symptoms, extinction retention, and neural activation in the amygdala, hippocampus, and anterior cingulate cortex (ACC).http://www.sciencedirect.com/science/article/pii/S1878929325000908AdolescenceFMRIFear extinctionFear learningFear conditioningChildren |
| spellingShingle | Sneha Bhargava Clara G. Zundel MacKenna Shampine Samantha Ely Carmen Carpenter Jennifer Losiowski Shravya Chanamolu Jovan Jande Reem Tamimi Kamakashi Sharma Emilie O’Mara Alaina M. Jaster Hilary A. Marusak Puberty, sex, and fear extinction retention: A neuroimaging study in youth Developmental Cognitive Neuroscience Adolescence FMRI Fear extinction Fear learning Fear conditioning Children |
| title | Puberty, sex, and fear extinction retention: A neuroimaging study in youth |
| title_full | Puberty, sex, and fear extinction retention: A neuroimaging study in youth |
| title_fullStr | Puberty, sex, and fear extinction retention: A neuroimaging study in youth |
| title_full_unstemmed | Puberty, sex, and fear extinction retention: A neuroimaging study in youth |
| title_short | Puberty, sex, and fear extinction retention: A neuroimaging study in youth |
| title_sort | puberty sex and fear extinction retention a neuroimaging study in youth |
| topic | Adolescence FMRI Fear extinction Fear learning Fear conditioning Children |
| url | http://www.sciencedirect.com/science/article/pii/S1878929325000908 |
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