Eosinophils: old cells, new directions
Eosinophils are polymorphonuclear cells that have progressively gained attention due to their involvement in multiple diseases and, more recently, in various homeostatic processes. Their well-known roles range from asthma and parasitic infections to less prevalent diseases such as eosinophilic granu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470381/full |
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| author | Alejandra Sanchez Santos Iovanna Socorro Avila Helena Galvan Fernandez Sara Cazorla Rivero Sara Cazorla Rivero Angelina Lemes Castellano Carlos Cabrera Lopez |
| author_facet | Alejandra Sanchez Santos Iovanna Socorro Avila Helena Galvan Fernandez Sara Cazorla Rivero Sara Cazorla Rivero Angelina Lemes Castellano Carlos Cabrera Lopez |
| author_sort | Alejandra Sanchez Santos |
| collection | DOAJ |
| description | Eosinophils are polymorphonuclear cells that have progressively gained attention due to their involvement in multiple diseases and, more recently, in various homeostatic processes. Their well-known roles range from asthma and parasitic infections to less prevalent diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic esophagitis, and hypereosinophilic syndrome. In recent years, various biological therapies targeting these cells have been developed, altering the course of eosinophilic pathologies. Recent research has demonstrated differences in eosinophil subtypes and their functions. The presence of distinct classes of eosinophils has led to the theory of resident eosinophils (rEos) and inflammatory eosinophils (iEos). Subtype differences are determined by the pattern of protein expression on the cell membrane and the localization of eosinophils. Most of this research has been conducted in murine models, but several studies confirm these findings in peripheral blood and tissue. The objective of this review is to provide a comprehensive analysis of eosinophils, by recent findings that divide this cell line into two distinct populations with different functions and purposes. |
| format | Article |
| id | doaj-art-7cf803e32cca466f8badeecc52abe1a3 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-7cf803e32cca466f8badeecc52abe1a32025-01-16T15:06:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14703811470381Eosinophils: old cells, new directionsAlejandra Sanchez Santos0Iovanna Socorro Avila1Helena Galvan Fernandez2Sara Cazorla Rivero3Sara Cazorla Rivero4Angelina Lemes Castellano5Carlos Cabrera Lopez6Hospital Universitario de Gran Canaria Dr. Negrín, Respiratory Service, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Respiratory Service, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Respiratory Service, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Research Unit, Las Palmas de Gran Canaria, SpainUniversidad de La Laguna, Research Unit, Santa Cruz de Tenerife, SpainHospital Universitario de Gran Canaria Dr. Negrín, Hematology Service, Las Palmas de Gran Canaria, SpainHospital Universitario de Gran Canaria Dr. Negrín, Respiratory Service, Las Palmas de Gran Canaria, SpainEosinophils are polymorphonuclear cells that have progressively gained attention due to their involvement in multiple diseases and, more recently, in various homeostatic processes. Their well-known roles range from asthma and parasitic infections to less prevalent diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic esophagitis, and hypereosinophilic syndrome. In recent years, various biological therapies targeting these cells have been developed, altering the course of eosinophilic pathologies. Recent research has demonstrated differences in eosinophil subtypes and their functions. The presence of distinct classes of eosinophils has led to the theory of resident eosinophils (rEos) and inflammatory eosinophils (iEos). Subtype differences are determined by the pattern of protein expression on the cell membrane and the localization of eosinophils. Most of this research has been conducted in murine models, but several studies confirm these findings in peripheral blood and tissue. The objective of this review is to provide a comprehensive analysis of eosinophils, by recent findings that divide this cell line into two distinct populations with different functions and purposes.https://www.frontiersin.org/articles/10.3389/fmed.2024.1470381/fullasthmaCOPDeosinophilssubtypesinflammation |
| spellingShingle | Alejandra Sanchez Santos Iovanna Socorro Avila Helena Galvan Fernandez Sara Cazorla Rivero Sara Cazorla Rivero Angelina Lemes Castellano Carlos Cabrera Lopez Eosinophils: old cells, new directions Frontiers in Medicine asthma COPD eosinophils subtypes inflammation |
| title | Eosinophils: old cells, new directions |
| title_full | Eosinophils: old cells, new directions |
| title_fullStr | Eosinophils: old cells, new directions |
| title_full_unstemmed | Eosinophils: old cells, new directions |
| title_short | Eosinophils: old cells, new directions |
| title_sort | eosinophils old cells new directions |
| topic | asthma COPD eosinophils subtypes inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470381/full |
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