Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers
**Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and a...
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| Format: | Article |
| Language: | English |
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Columbia Data Analytics, LLC
2016-10-01
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| Series: | Journal of Health Economics and Outcomes Research |
| Online Access: | https://doi.org/10.36469/9842 |
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| author | Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor |
| author_facet | Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor |
| author_sort | Emuella Flood |
| collection | DOAJ |
| description | **Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and atomoxetine (ATX) are two non-stimulant medications approved in the United States for the treatment of ADHD.
**Objective:** To identify non-stimulant ADHD medication attributes important to caregivers/patients.
**Methods:** US caregivers of ADHD patients (6–17 years) and child/adolescent patients (10–17 years) completed an adaptive conjoint analysis survey. Respondents selected between hypothetical treatments with different attributes. Ordinary least-squares and hierarchical Bayes regression using Sawtooth Software were used to calculate utilities, importance ratings, and preferences.
**Results:** 483 caregivers (mean age: 41.9 years, standard deviation [SD]: 8.7; 75% female) and 211 children/adolescents (mean age: 14.5 years, SD: 2.2; 70% male) completed the survey. Based on importance ratings, the most influential attributes for both caregivers and children/adolescents were chance of somnolence, efficacy, and for caregivers, effect on oppositionality and black box warning. Most caregivers (95.3%) and children/adolescents (93.8%) preferred GXR over ATX. In several sensitivity analyses in which attribute levels varied, GXR remained the preferred medication with the exception of one scenario.
**Conclusions:** Children/adolescents and caregivers demonstrated in this study that they can clearly express their preferences for treatment attributes and treatment choices; in this case they preferred GXR to ATX. Patients and caregiver preferences could be useful inputs to the treatment selection decision-making process. |
| format | Article |
| id | doaj-art-7cf2505f2eab4ecdb556b525af8ad5eb |
| institution | Kabale University |
| issn | 2327-2236 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Columbia Data Analytics, LLC |
| record_format | Article |
| series | Journal of Health Economics and Outcomes Research |
| spelling | doaj-art-7cf2505f2eab4ecdb556b525af8ad5eb2025-02-10T16:12:42ZengColumbia Data Analytics, LLCJournal of Health Economics and Outcomes Research2327-22362016-10-0131Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their CaregiversEmuella FloodKavita GajriaVanja SikiricaPaul HodgkinsM. Haim ErderFrank LopezDaniel Connor**Background:** Understanding patient and caregiver preferences for treatment is important for optimizing treatment decisions. Non-stimulant therapies are an alternative treatment option to stimulant therapy for attention-deficit/hyperactivity disorder (ADHD). Guanfacine extended release (GXR) and atomoxetine (ATX) are two non-stimulant medications approved in the United States for the treatment of ADHD. **Objective:** To identify non-stimulant ADHD medication attributes important to caregivers/patients. **Methods:** US caregivers of ADHD patients (6–17 years) and child/adolescent patients (10–17 years) completed an adaptive conjoint analysis survey. Respondents selected between hypothetical treatments with different attributes. Ordinary least-squares and hierarchical Bayes regression using Sawtooth Software were used to calculate utilities, importance ratings, and preferences. **Results:** 483 caregivers (mean age: 41.9 years, standard deviation [SD]: 8.7; 75% female) and 211 children/adolescents (mean age: 14.5 years, SD: 2.2; 70% male) completed the survey. Based on importance ratings, the most influential attributes for both caregivers and children/adolescents were chance of somnolence, efficacy, and for caregivers, effect on oppositionality and black box warning. Most caregivers (95.3%) and children/adolescents (93.8%) preferred GXR over ATX. In several sensitivity analyses in which attribute levels varied, GXR remained the preferred medication with the exception of one scenario. **Conclusions:** Children/adolescents and caregivers demonstrated in this study that they can clearly express their preferences for treatment attributes and treatment choices; in this case they preferred GXR to ATX. Patients and caregiver preferences could be useful inputs to the treatment selection decision-making process.https://doi.org/10.36469/9842 |
| spellingShingle | Emuella Flood Kavita Gajria Vanja Sikirica Paul Hodgkins M. Haim Erder Frank Lopez Daniel Connor Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers Journal of Health Economics and Outcomes Research |
| title | Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
| title_full | Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
| title_fullStr | Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
| title_full_unstemmed | Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
| title_short | Preferences for Attention-Deficit/Hyperactivity Disorder (ADHD) Non-Stimulant Treatment Characteristics Among Children and Adolescents With ADHD and Their Caregivers |
| title_sort | preferences for attention deficit hyperactivity disorder adhd non stimulant treatment characteristics among children and adolescents with adhd and their caregivers |
| url | https://doi.org/10.36469/9842 |
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