Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

Prolonged Omicron-specific B cell maturation alleviates immune imprinting induced by SARS-CoV-2 inactivated vaccine

SARS-CoV-2 ancestral strain-induced immune imprinting poses great challenges to updating vaccines for new variants. Studies showed that repeated Omicron exposures could override immune imprinting induced by inactivated vaccines but not mRNA vaccines, a disparity yet to be understood. Here, we analyz...

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Bibliographic Details
Main Authors: Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Ran An, Yao Wang, Haiyan Sun, Peng Wang, Lingling Yu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Yunlong Cao
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Omicron breakthrough infection
immune imprinting
antibody responses
epitope distribution
SARS-CoV-2 RBD
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2412623
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