Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis
Background: Immune thrombocytopenia (ITP) is an uncommon but serious adverse reaction after vaccination. However, its association with vaccines other than the measles–mumps–rubella vaccine remains debatable. This study aimed to analyze ITP cases following influenza vaccination and assess any potenti...
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MDPI AG
2024-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/11/1298 |
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| author | Zhicai Liu Jing Wang Zhaojun Lu Yuyang Xu Jian Du Jiayin Han Xuechao Zhang Yan Liu |
| author_facet | Zhicai Liu Jing Wang Zhaojun Lu Yuyang Xu Jian Du Jiayin Han Xuechao Zhang Yan Liu |
| author_sort | Zhicai Liu |
| collection | DOAJ |
| description | Background: Immune thrombocytopenia (ITP) is an uncommon but serious adverse reaction after vaccination. However, its association with vaccines other than the measles–mumps–rubella vaccine remains debatable. This study aimed to analyze ITP cases following influenza vaccination and assess any potential association. Methods: We performed a systematic search of the Web of Science, Embase, and PubMed databases from their inception to 15 April 2024. Cases were characterized qualitatively, and relative risk was assessed using either fixed or random models. Results: A total of 24 studies were analyzed, including 16 patients from 14 case reports. Patients averaged 56.7 years old, half were female, and ten patients had a history of prior illness. The mean time between vaccination and diagnosis was 13.3 days. Treatment primarily involved corticosteroids or intravenous immunoglobulin, with most recovering within a month. The pooled odds ratio for ITP post-influenza vaccination was 0.94 (95%CI: 0.85–1.03). Subgroup analyses conducted according to the study design and vaccine type did not reveal any significant results. Conclusion: No evidence of an association between influenza vaccination and ITP was found. Further observational studies are required to verify this relationship. |
| format | Article |
| id | doaj-art-7ce93135cac54ceaaccc87e8328c14fe |
| institution | OA Journals |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-7ce93135cac54ceaaccc87e8328c14fe2025-08-20T02:04:44ZengMDPI AGVaccines2076-393X2024-11-011211129810.3390/vaccines12111298Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-AnalysisZhicai Liu0Jing Wang1Zhaojun Lu2Yuyang Xu3Jian Du4Jiayin Han5Xuechao Zhang6Yan Liu7Department of Public Health, Medical School of Ningbo University, Ningbo 315211, ChinaDepartment of Infectious Disease Control and Prevention, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution), Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaDepartment of Expanded Program on Immunization, Hangzhou Center for Diseases Control and Prevention (Hangzhou Health Supervision Institution) Hangzhou 310021, ChinaBackground: Immune thrombocytopenia (ITP) is an uncommon but serious adverse reaction after vaccination. However, its association with vaccines other than the measles–mumps–rubella vaccine remains debatable. This study aimed to analyze ITP cases following influenza vaccination and assess any potential association. Methods: We performed a systematic search of the Web of Science, Embase, and PubMed databases from their inception to 15 April 2024. Cases were characterized qualitatively, and relative risk was assessed using either fixed or random models. Results: A total of 24 studies were analyzed, including 16 patients from 14 case reports. Patients averaged 56.7 years old, half were female, and ten patients had a history of prior illness. The mean time between vaccination and diagnosis was 13.3 days. Treatment primarily involved corticosteroids or intravenous immunoglobulin, with most recovering within a month. The pooled odds ratio for ITP post-influenza vaccination was 0.94 (95%CI: 0.85–1.03). Subgroup analyses conducted according to the study design and vaccine type did not reveal any significant results. Conclusion: No evidence of an association between influenza vaccination and ITP was found. Further observational studies are required to verify this relationship.https://www.mdpi.com/2076-393X/12/11/1298Immune thrombocytopeniapurpurainfluenzavaccinationmeta-analysis |
| spellingShingle | Zhicai Liu Jing Wang Zhaojun Lu Yuyang Xu Jian Du Jiayin Han Xuechao Zhang Yan Liu Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis Vaccines Immune thrombocytopenia purpura influenza vaccination meta-analysis |
| title | Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis |
| title_full | Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis |
| title_fullStr | Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis |
| title_short | Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis |
| title_sort | association between influenza vaccine and immune thrombocytopenia a systematic review and meta analysis |
| topic | Immune thrombocytopenia purpura influenza vaccination meta-analysis |
| url | https://www.mdpi.com/2076-393X/12/11/1298 |
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