Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

Abstract Sydenham chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF). ARF and rheumatic heart disease (RHD) are autoimmune complications triggered by a group A streptococcal (GAS) infection. In ARF/RHD and SC, tissue cross‐reactive antibodies and T‐cells genera...

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Main Authors: Rukshan Ahamed Mohamed Rafeek, Riya Thapa, Samarjeet Saluja, Bipandeep Banga, David McMillan, Kadaba Sri Sriprakash, Nicholas M. Andronicos, Adam Hamlin, Natkunam Ketheesan
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Animal Models and Experimental Medicine
Subjects:
animal model
blood–brain‐barrier
group a streptococcus
rheumatic fever
Sydenham's chorea
Online Access:https://doi.org/10.1002/ame2.70012
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