Time to Platelet Recovery in Patients with Severe Dengue Post Transfusion with Fresh Frozen Plasma and Platelet-rich Concentrate versus Platelet-rich Concentrate Alone: An Observational Study
Background and Objective: Life-threatening bleed in severe dengue may justify the need for product transfusion. Earlier, only platelet-rich concentrates were transfused but recently transfusion with fresh frozen plasma (FFP) followed by platelet rich concentrate is done as thrombocytopenia in dengue...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | CHRISMED Journal of Health and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/cjhr.cjhr_109_23 |
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| Summary: | Background and Objective:
Life-threatening bleed in severe dengue may justify the need for product transfusion. Earlier, only platelet-rich concentrates were transfused but recently transfusion with fresh frozen plasma (FFP) followed by platelet rich concentrate is done as thrombocytopenia in dengue is thought to be due to a mismatch between von Willebrand factor and ADAMTS13. We aimed to see which of the above modes of transfusion hastened recovery of platelet count to more than 50,000/mm3.
Methods:
A retrospective observational study was done in 101 patients with dengue for10 years admitted under a single medicine unit in a tertiary center in South India.
Results:
The mean number of days for platelets to reach 50,000/mm3 from the day of the first transfusion was 2.5 days (n = 60) for those who received FFP and platelet-rich concentrate, whereas it was 2.4 days (n = 41) for those who received only platelet-rich concentrate alone.
Conclusion:
There was no significant difference in time to recovery of platelet levels between the two groups. |
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| ISSN: | 2348-3334 2348-506X |