Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study
Abstract Anemia remains a significant global health challenge, driven by complex inflammatory mechanisms. This study investigated the association between neutrophil percentage-to-albumin ratio (NPAR) and anemia risk, utilizing data from 24,938 participants in the National Health and Nutrition Examin...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-98708-3 |
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| author | Songting Gao Fuqin Yu Yueyuan Han |
| author_facet | Songting Gao Fuqin Yu Yueyuan Han |
| author_sort | Songting Gao |
| collection | DOAJ |
| description | Abstract Anemia remains a significant global health challenge, driven by complex inflammatory mechanisms. This study investigated the association between neutrophil percentage-to-albumin ratio (NPAR) and anemia risk, utilizing data from 24,938 participants in the National Health and Nutrition Examination Survey (2005–2018). Multivariable logistic regression analysis revealed a significant association between NPAR and anemia risk (OR = 1.16; 95% CI 1.13–1.18, p < 0.0001). Two-piecewise regression analysis identified a nonlinear relationship with a threshold at NPAR 11.96: below this threshold, an inverse association was observed (OR = 0.88; 95% CI 0.79–0.98, p = 0.0249), while above it, a positive association was evident (OR = 1.21; 95% CI 1.18–1.25, p < 0.0001). Subgroup analyses demonstrated stronger associations in males, non-Hispanic Whites, diabetic patients, and individuals who were married or living with a partner. These findings highlight the potential of NPAR as a novel biomarker for assessing anemia risk in clinical practice. |
| format | Article |
| id | doaj-art-7ce21cdbd8ef41d3800038cbb030d5bb |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-7ce21cdbd8ef41d3800038cbb030d5bb2025-08-20T02:32:07ZengNature PortfolioScientific Reports2045-23222025-05-0115111510.1038/s41598-025-98708-3Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based studySongting Gao0Fuqin Yu1Yueyuan Han2Guali Branch of the First People’s Hospital of Xiaoshan DistrictGuali Branch of the First People’s Hospital of Xiaoshan DistrictThe First People’s Hospital of Xiaoshan DistrictAbstract Anemia remains a significant global health challenge, driven by complex inflammatory mechanisms. This study investigated the association between neutrophil percentage-to-albumin ratio (NPAR) and anemia risk, utilizing data from 24,938 participants in the National Health and Nutrition Examination Survey (2005–2018). Multivariable logistic regression analysis revealed a significant association between NPAR and anemia risk (OR = 1.16; 95% CI 1.13–1.18, p < 0.0001). Two-piecewise regression analysis identified a nonlinear relationship with a threshold at NPAR 11.96: below this threshold, an inverse association was observed (OR = 0.88; 95% CI 0.79–0.98, p = 0.0249), while above it, a positive association was evident (OR = 1.21; 95% CI 1.18–1.25, p < 0.0001). Subgroup analyses demonstrated stronger associations in males, non-Hispanic Whites, diabetic patients, and individuals who were married or living with a partner. These findings highlight the potential of NPAR as a novel biomarker for assessing anemia risk in clinical practice.https://doi.org/10.1038/s41598-025-98708-3NPARAnemiaNHANESInflammation marker |
| spellingShingle | Songting Gao Fuqin Yu Yueyuan Han Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study Scientific Reports NPAR Anemia NHANES Inflammation marker |
| title | Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study |
| title_full | Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study |
| title_fullStr | Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study |
| title_full_unstemmed | Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study |
| title_short | Association between Neutrophil Percentage-to-Albumin ratio and anemia risk: a population-based study |
| title_sort | association between neutrophil percentage to albumin ratio and anemia risk a population based study |
| topic | NPAR Anemia NHANES Inflammation marker |
| url | https://doi.org/10.1038/s41598-025-98708-3 |
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