Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study
Background: Brain atrophy is a common finding in older people. However, in some cases, brain atrophy is not proportional to the patient’s age. Recently, there has been much focus on the neurotoxicity of anesthetic drugs. Objectives: This study was planned to investigate whether exposure to anesthes...
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Guilan University of Medical Sciences
2025-01-01
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| Series: | Caspian Journal of Neurological Sciences |
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| Online Access: | http://cjns.gums.ac.ir/article-1-740-en.pdf |
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| author | Zoubin Souri Mahsa Eghrari Gigloo Soheil Soltanipour Hakimeh Sarshad Gelareh Biazar |
| author_facet | Zoubin Souri Mahsa Eghrari Gigloo Soheil Soltanipour Hakimeh Sarshad Gelareh Biazar |
| author_sort | Zoubin Souri |
| collection | DOAJ |
| description | Background: Brain atrophy is a common finding in older people. However, in some cases, brain atrophy is not proportional to the patient’s age. Recently, there has been much focus on the neurotoxicity of anesthetic drugs.
Objectives: This study was planned to investigate whether exposure to anesthesia accelerates the process of brain atrophy.
Materials & Methods: This case-control study was conducted in two academic hospitals affiliated with Guilan University of Medical Sciences (GUMS), Rasht City, Iran, from May 2024 to August 2024. Patients with early brain atrophy were included as the case group, and those who did not have early brain atrophy as the control group; 27 people in each group were studied. A checklist containing demographic data, history of receiving anesthesia, age of receiving anesthesia, and number of times receiving anesthesia was completed and the obtained data were compared between the two groups.
Results: Regarding demographic data, no significant difference was observed between the two groups (P>0.05). Although early brain atrophy was more common in older people (62.59±8 vs 58±10.5 years), the difference was not significant (P=0.069). Two groups were also compared in terms of diabetes (P=0.054), hypertension (P=0.248), stroke (P=0.34), alcohol consumption and addiction (P=0.552). Regarding the history of receiving general anesthesia as the main variable of the study, the difference between the two groups was not significant (P=0.78).
Conclusion: The results of this study did not show a significant association between receiving general anesthesia and early brain atrophy. However, given the remarkable limitations of this study and the valid evidence, well-planned future studies are welcome. |
| format | Article |
| id | doaj-art-7cdf3fabb83f421abcff67100ebdc912 |
| institution | Kabale University |
| issn | 2423-4818 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Guilan University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Neurological Sciences |
| spelling | doaj-art-7cdf3fabb83f421abcff67100ebdc9122025-02-04T11:29:02ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2423-48182025-01-011115157Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control StudyZoubin Souri0Mahsa Eghrari Gigloo1Soheil Soltanipour2Hakimeh Sarshad3Gelareh Biazar4 Department of Radiology, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Anesthesiology, Anesthesiology Research Center, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Community Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Department of Anesthesiology, Anesthesiology Research Center, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran. Department of Anesthesiology, Anesthesiology Research Center, Alzahra hospital, Guilan University of Medical Sciences, Rasht, Iran. Background: Brain atrophy is a common finding in older people. However, in some cases, brain atrophy is not proportional to the patient’s age. Recently, there has been much focus on the neurotoxicity of anesthetic drugs. Objectives: This study was planned to investigate whether exposure to anesthesia accelerates the process of brain atrophy. Materials & Methods: This case-control study was conducted in two academic hospitals affiliated with Guilan University of Medical Sciences (GUMS), Rasht City, Iran, from May 2024 to August 2024. Patients with early brain atrophy were included as the case group, and those who did not have early brain atrophy as the control group; 27 people in each group were studied. A checklist containing demographic data, history of receiving anesthesia, age of receiving anesthesia, and number of times receiving anesthesia was completed and the obtained data were compared between the two groups. Results: Regarding demographic data, no significant difference was observed between the two groups (P>0.05). Although early brain atrophy was more common in older people (62.59±8 vs 58±10.5 years), the difference was not significant (P=0.069). Two groups were also compared in terms of diabetes (P=0.054), hypertension (P=0.248), stroke (P=0.34), alcohol consumption and addiction (P=0.552). Regarding the history of receiving general anesthesia as the main variable of the study, the difference between the two groups was not significant (P=0.78). Conclusion: The results of this study did not show a significant association between receiving general anesthesia and early brain atrophy. However, given the remarkable limitations of this study and the valid evidence, well-planned future studies are welcome.http://cjns.gums.ac.ir/article-1-740-en.pdfgeneral anesthesiapoisoningnervous systembrain atrophy |
| spellingShingle | Zoubin Souri Mahsa Eghrari Gigloo Soheil Soltanipour Hakimeh Sarshad Gelareh Biazar Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study Caspian Journal of Neurological Sciences general anesthesia poisoning nervous system brain atrophy |
| title | Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study |
| title_full | Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study |
| title_fullStr | Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study |
| title_full_unstemmed | Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study |
| title_short | Investigating the Relationship Between General Anesthesia and Early Brain Atrophy: A Case-control Study |
| title_sort | investigating the relationship between general anesthesia and early brain atrophy a case control study |
| topic | general anesthesia poisoning nervous system brain atrophy |
| url | http://cjns.gums.ac.ir/article-1-740-en.pdf |
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