The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

The Induction and Characterization of a Potential Rough‐Type Brucella Vaccine Candidate Strain RA343, and Its Safety, Protective Efficacy in Mouse and Guinea Pig Models

ABSTRACT Brucellosis is a zoonotic disease caused by Brucella spp. which seriously jeopardizes the health and safety of animals and human beings. Therefore, developing a live attenuated vaccine is a priority. In this study, a genetically stable Brucella rough RA343 strain was obtained by cross‐induc...

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Main Authors: Linjiao Li, Guangzhi Zhang, Minghe Liu, Lang Lv, Xiaowei Peng, Yu Feng, Xiaotong Yang, Jiabo Ding, Chunhai Liu, Jianhua Qin, Peng Li, Hui Jiang, Xuezheng Fan
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Animal Research and One Health
Subjects:
brucellosis
protective efficacy
RNA‐seq analysis
vaccines
Online Access:https://doi.org/10.1002/aro2.70001
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