Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies
The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. The occurrence and development of these diseas...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000040 |
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| author | Yanjiao Zhang Kaile Ma Xinyi Fang Yuxin Zhang Runyu Miao Huifang Guan Jiaxing Tian |
| author_facet | Yanjiao Zhang Kaile Ma Xinyi Fang Yuxin Zhang Runyu Miao Huifang Guan Jiaxing Tian |
| author_sort | Yanjiao Zhang |
| collection | DOAJ |
| description | The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. The occurrence and development of these diseases are closely related to the disruption of ion homeostasis, which is crucial for maintaining cellular functions and metabolic equilibrium. However, the specific mechanism of ion homeostasis in metabolic diseases is still unclear. This article reviews the role of ion homeostasis in the pathogenesis of metabolic diseases and assesses its potential as a therapeutic target. Furthermore, the article explores pharmacological strategies that target ion channels and transporters, including existing drugs and emerging drugs under development. Lastly, the article discusses the development direction of future therapeutic strategies, including the possibility of gene therapy targeting specific ion channels and personalized therapy using novel biomarkers. In summary, targeting ion homeostasis provides a new perspective and potential therapeutic approach for the treatment of metabolic diseases. |
| format | Article |
| id | doaj-art-7cdc40ba21ce426298ebaccb76ec961b |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-7cdc40ba21ce426298ebaccb76ec961b2025-02-08T04:59:39ZengElsevierPharmacological Research1096-11862025-02-01212107579Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapiesYanjiao Zhang0Kaile Ma1Xinyi Fang2Yuxin Zhang3Runyu Miao4Huifang Guan5Jiaxing Tian6Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaInstitute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaInstitute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Graduate College, Beijing University of Chinese Medicine, Beijing 100029, ChinaInstitute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaInstitute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Graduate College, Beijing University of Chinese Medicine, Beijing 100029, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, ChinaInstitute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Corresponding author.The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. The occurrence and development of these diseases are closely related to the disruption of ion homeostasis, which is crucial for maintaining cellular functions and metabolic equilibrium. However, the specific mechanism of ion homeostasis in metabolic diseases is still unclear. This article reviews the role of ion homeostasis in the pathogenesis of metabolic diseases and assesses its potential as a therapeutic target. Furthermore, the article explores pharmacological strategies that target ion channels and transporters, including existing drugs and emerging drugs under development. Lastly, the article discusses the development direction of future therapeutic strategies, including the possibility of gene therapy targeting specific ion channels and personalized therapy using novel biomarkers. In summary, targeting ion homeostasis provides a new perspective and potential therapeutic approach for the treatment of metabolic diseases.http://www.sciencedirect.com/science/article/pii/S1043661825000040Ion homeostasisMetabolic diseasesMolecular mechanismsTargeted therapiesDiabetes |
| spellingShingle | Yanjiao Zhang Kaile Ma Xinyi Fang Yuxin Zhang Runyu Miao Huifang Guan Jiaxing Tian Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies Pharmacological Research Ion homeostasis Metabolic diseases Molecular mechanisms Targeted therapies Diabetes |
| title | Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies |
| title_full | Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies |
| title_fullStr | Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies |
| title_full_unstemmed | Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies |
| title_short | Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies |
| title_sort | targeting ion homeostasis in metabolic diseases molecular mechanisms and targeted therapies |
| topic | Ion homeostasis Metabolic diseases Molecular mechanisms Targeted therapies Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000040 |
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