Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer
Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been implicated in some tumor types, but its role in primary prostate cancer (PCa) remains unexplored. This study investigates the prognostic significance of PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical info...
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| Format: | Article |
| Language: | English |
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MRE Press
2024-11-01
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| Series: | Journal of Men's Health |
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| Online Access: | https://oss.jomh.org/files/article/20230928-100/pdf/JOMH2024061204.pdf |
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| author | Jianming Lu Yunze Fang Jiexin Luo Runxin Zhou Le Zhang Chao Cai Zhengguo Cao Rujun Mo |
| author_facet | Jianming Lu Yunze Fang Jiexin Luo Runxin Zhou Le Zhang Chao Cai Zhengguo Cao Rujun Mo |
| author_sort | Jianming Lu |
| collection | DOAJ |
| description | Phosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been
implicated in some tumor types, but its role in primary prostate cancer (PCa)
remains unexplored. This study investigates the prognostic significance of
PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical information
on PCa cohorts were retrieved from the The Cancer Genome Atlas Program (TCGA) and
Gene Expression Omnibus (GEO) databases. Data analysis revealed that PITPNC1
expression was significantly lower in PCa tissues compared to benign tissues, and
this reduced expression correlated with earlier biochemical recurrence and
decreased overall survival. Functional enrichment analysis indicated that PITPNC1
activates pathways related to cell adhesion and immune receptor signaling while
inhibiting RNA metabolism pathways. Additionally, high Tumor Protein P53
(TP53) mutation frequency was observed in the low PITPNC1 expression
group. In immunotherapy cohorts, lower PITPNC1 expression was associated with
poorer outcomes. Furthermore, Rucaparib was identified as a potential therapeutic
agent for patients with low PITPNC1 expression. Collectively, we identified
PITPNC1 as a promising prognostic marker in PCa. Its expression levels can
predict immunotherapy responses, and it holds potential as a target for precision
therapies. |
| format | Article |
| id | doaj-art-7cd685e9534b4dba9002b9b535f4eac3 |
| institution | DOAJ |
| issn | 1875-6867 1875-6859 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj-art-7cd685e9534b4dba9002b9b535f4eac32025-08-20T02:50:23ZengMRE PressJournal of Men's Health1875-68671875-68592024-11-01201113614610.22514/jomh.2024.194S1875-6867(24)00302-6Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancerJianming Lu0Yunze Fang1Jiexin Luo2Runxin Zhou3Le Zhang4Chao Cai5Zhengguo Cao6Rujun Mo7Department of Andrology, Guangzhou First People’s Hospital, Guangzhou Medical University, 510180 Guangzhou, Guangdong, ChinaDepartment of Urology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), 523059 Dongguan, Guangdong, ChinaDepartment of Urology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), 523059 Dongguan, Guangdong, ChinaGraduate School, Guangdong Medical University, 524002 Zhanjiang, Guangdong, ChinaInstitute for Integrative Genome Biology, University of California Riverside, Riverside, CA 92521, USADepartment of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Key Laboratory of Urology, Guangzhou Institute of Urology, 510230 Guangzhou, Guangdong, ChinaDepartment of Urology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), 523059 Dongguan, Guangdong, ChinaDepartment of Urology, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital), 523059 Dongguan, Guangdong, ChinaPhosphatidylinositol transfer protein cytoplasmic 1 (PITPNC1) has been implicated in some tumor types, but its role in primary prostate cancer (PCa) remains unexplored. This study investigates the prognostic significance of PITPNC1 in PCa. RNA sequencing (RNA-seq), mutation data and clinical information on PCa cohorts were retrieved from the The Cancer Genome Atlas Program (TCGA) and Gene Expression Omnibus (GEO) databases. Data analysis revealed that PITPNC1 expression was significantly lower in PCa tissues compared to benign tissues, and this reduced expression correlated with earlier biochemical recurrence and decreased overall survival. Functional enrichment analysis indicated that PITPNC1 activates pathways related to cell adhesion and immune receptor signaling while inhibiting RNA metabolism pathways. Additionally, high Tumor Protein P53 (TP53) mutation frequency was observed in the low PITPNC1 expression group. In immunotherapy cohorts, lower PITPNC1 expression was associated with poorer outcomes. Furthermore, Rucaparib was identified as a potential therapeutic agent for patients with low PITPNC1 expression. Collectively, we identified PITPNC1 as a promising prognostic marker in PCa. Its expression levels can predict immunotherapy responses, and it holds potential as a target for precision therapies.https://oss.jomh.org/files/article/20230928-100/pdf/JOMH2024061204.pdfprostate cancerpitpnc1biochemical recurrencetp53immunotherapy |
| spellingShingle | Jianming Lu Yunze Fang Jiexin Luo Runxin Zhou Le Zhang Chao Cai Zhengguo Cao Rujun Mo Prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer Journal of Men's Health prostate cancer pitpnc1 biochemical recurrence tp53 immunotherapy |
| title | Prognostic role and therapeutic implications of phosphatidylinositol
transfer protein cytoplasmic 1 in primary prostate cancer |
| title_full | Prognostic role and therapeutic implications of phosphatidylinositol
transfer protein cytoplasmic 1 in primary prostate cancer |
| title_fullStr | Prognostic role and therapeutic implications of phosphatidylinositol
transfer protein cytoplasmic 1 in primary prostate cancer |
| title_full_unstemmed | Prognostic role and therapeutic implications of phosphatidylinositol
transfer protein cytoplasmic 1 in primary prostate cancer |
| title_short | Prognostic role and therapeutic implications of phosphatidylinositol
transfer protein cytoplasmic 1 in primary prostate cancer |
| title_sort | prognostic role and therapeutic implications of phosphatidylinositol transfer protein cytoplasmic 1 in primary prostate cancer |
| topic | prostate cancer pitpnc1 biochemical recurrence tp53 immunotherapy |
| url | https://oss.jomh.org/files/article/20230928-100/pdf/JOMH2024061204.pdf |
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