Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress
Emerging chemicals (ECs), including parabens, bisphenols, bisphenol diglycidyl ethers, N,N′-substituted p-phenylenediamines, and benzotriazoles/benzothiazoles (BTH/BTRs), are widely used in industrial and consumer products. This study aimed to determine the urinary concentrations of 33 ECs and three...
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KeAi Communications Co., Ltd.
2025-06-01
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| author | Henglin Zhang Yuxian Liu Yanan Zhao Jiye Zhang Luhan Yang Guanglan Zhang Yanpeng Cai Lan Yang Jianya Xi Ziliang Wang Hong Liang Maohua Miao Tao Zhang Jingchuan Xue |
| author_facet | Henglin Zhang Yuxian Liu Yanan Zhao Jiye Zhang Luhan Yang Guanglan Zhang Yanpeng Cai Lan Yang Jianya Xi Ziliang Wang Hong Liang Maohua Miao Tao Zhang Jingchuan Xue |
| author_sort | Henglin Zhang |
| collection | DOAJ |
| description | Emerging chemicals (ECs), including parabens, bisphenols, bisphenol diglycidyl ethers, N,N′-substituted p-phenylenediamines, and benzotriazoles/benzothiazoles (BTH/BTRs), are widely used in industrial and consumer products. This study aimed to determine the urinary concentrations of 33 ECs and three oxidative stress biomarkers in pregnant women from a large birth cohort in Jiashan, China. Among the detected compounds, methyl paraben (MeP), bisphenol A (BPA), bisphenol A bis(2,3-dihydroxypropyl) glycidyl ether (BADGE·2H2O), N-isopropyl-N′-phenyl-1,4-phenylenediamine quinone (IPPDQ), and 1H-benzotriazole (1-H-BTR) were the most prevalent, with median concentrations ranging from 0.51 to 9.02 ng/mL. Notably, BTH/BTRs exhibited the highest exposure levels, approximately 4–16 times greater than those of other ECs. Most ECs showed elevated concentrations in pregnant women who were exposed to secondhand smoke prior to pregnancy. After model analysis, we found that mixtures of ECs were positively associated with both 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 15(R)-prostaglandin F2α (15-PGF2α), while a negative trend was observed between ECs and 8-iso-prostaglandin F2α (8-PGF2α). Specifically, urinary benzyl paraben (BzP), BPA, bisphenol S (BPS), N-(1,3-dimethylbutyl)-N′-phenyl-1,4-phenylenediamine quinone (6PPDQ), IPPDQ, 2(3H)-benzothiazole (2-OH-BTH), and 2-methylthio-benzothiazole (2-Me-S-BTH) or 1-H-BTR were significantly (p < 0.05) associated with 8-OHdG. MeP, 6PPDQ, and 2-Me-S-BTH were linked to 15-PGF2α, while only bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H2O) showed a significant positive association with 8-PGF2α. This study provides a comprehensive evaluation of the exposure characteristics of ECs and their associations with oxidative stress biomarkers in pregnant women, offering new insights into the health risks associated with ECs exposure during critical periods of pregnancy. |
| format | Article |
| id | doaj-art-7cd57f227dee45b3884e3da426588160 |
| institution | Kabale University |
| issn | 2405-6650 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Emerging Contaminants |
| spelling | doaj-art-7cd57f227dee45b3884e3da4265881602025-08-20T03:27:01ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502025-06-0111210050210.1016/j.emcon.2025.100502Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stressHenglin Zhang0Yuxian Liu1Yanan Zhao2Jiye Zhang3Luhan Yang4Guanglan Zhang5Yanpeng Cai6Lan Yang7Jianya Xi8Ziliang Wang9Hong Liang10Maohua Miao11Tao Zhang12Jingchuan Xue13School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, China; Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, ChinaKey Laboratory of Ministry of Education for Water Quality Security and Protection in Pearl River Delta, School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, ChinaGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, ChinaSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, ChinaSchool of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, ChinaDepartment of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510006, ChinaGuangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Humin Road, Shanghai, 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Humin Road, Shanghai, 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Humin Road, Shanghai, 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Humin Road, Shanghai, 200237, ChinaShanghai-MOST Key Laboratory of Health and Disease Genomics, NHC Key Lab of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 779 Lao Humin Road, Shanghai, 200237, China; Corresponding author. Shanghai Institute for Biomedical and Pharmaceutical Technologies, China.School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, China; School of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, 518107, China; Corresponding author. Sun Yat-Sen University, China.Guangdong Basic Research Center of Excellence for Ecological Security and Green Development, Key Laboratory for City Cluster Environmental Safety and Green Development of the Ministry of Education, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, Institute of Environmental and Ecological Engineering, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Provincial Observation and Research Station for Social-Natural Complex Ecosystems in Haizhu Wetlands, Guangzhou, 510320, China; Corresponding author. Guangdong University of Technology, China.Emerging chemicals (ECs), including parabens, bisphenols, bisphenol diglycidyl ethers, N,N′-substituted p-phenylenediamines, and benzotriazoles/benzothiazoles (BTH/BTRs), are widely used in industrial and consumer products. This study aimed to determine the urinary concentrations of 33 ECs and three oxidative stress biomarkers in pregnant women from a large birth cohort in Jiashan, China. Among the detected compounds, methyl paraben (MeP), bisphenol A (BPA), bisphenol A bis(2,3-dihydroxypropyl) glycidyl ether (BADGE·2H2O), N-isopropyl-N′-phenyl-1,4-phenylenediamine quinone (IPPDQ), and 1H-benzotriazole (1-H-BTR) were the most prevalent, with median concentrations ranging from 0.51 to 9.02 ng/mL. Notably, BTH/BTRs exhibited the highest exposure levels, approximately 4–16 times greater than those of other ECs. Most ECs showed elevated concentrations in pregnant women who were exposed to secondhand smoke prior to pregnancy. After model analysis, we found that mixtures of ECs were positively associated with both 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 15(R)-prostaglandin F2α (15-PGF2α), while a negative trend was observed between ECs and 8-iso-prostaglandin F2α (8-PGF2α). Specifically, urinary benzyl paraben (BzP), BPA, bisphenol S (BPS), N-(1,3-dimethylbutyl)-N′-phenyl-1,4-phenylenediamine quinone (6PPDQ), IPPDQ, 2(3H)-benzothiazole (2-OH-BTH), and 2-methylthio-benzothiazole (2-Me-S-BTH) or 1-H-BTR were significantly (p < 0.05) associated with 8-OHdG. MeP, 6PPDQ, and 2-Me-S-BTH were linked to 15-PGF2α, while only bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE·H2O) showed a significant positive association with 8-PGF2α. This study provides a comprehensive evaluation of the exposure characteristics of ECs and their associations with oxidative stress biomarkers in pregnant women, offering new insights into the health risks associated with ECs exposure during critical periods of pregnancy.http://www.sciencedirect.com/science/article/pii/S2405665025000368Pregnant womenUrineEmerging chemicalsOxidative stress |
| spellingShingle | Henglin Zhang Yuxian Liu Yanan Zhao Jiye Zhang Luhan Yang Guanglan Zhang Yanpeng Cai Lan Yang Jianya Xi Ziliang Wang Hong Liang Maohua Miao Tao Zhang Jingchuan Xue Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress Emerging Contaminants Pregnant women Urine Emerging chemicals Oxidative stress |
| title | Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress |
| title_full | Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress |
| title_fullStr | Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress |
| title_full_unstemmed | Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress |
| title_short | Urinary exposure level of emerging chemicals in Chinese pregnant women and their associations with oxidative stress |
| title_sort | urinary exposure level of emerging chemicals in chinese pregnant women and their associations with oxidative stress |
| topic | Pregnant women Urine Emerging chemicals Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2405665025000368 |
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