Correlates of HIV-1 genital shedding in Tanzanian women.
<h4>Background</h4>Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised...
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Public Library of Science (PLoS)
2011-03-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017480&type=printable |
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| author | Clare Tanton Helen A Weiss Jerome Le Goff John Changalucha Mary Rusizoka Kathy Baisley Dean Everett David A Ross Laurent Belec Richard J Hayes Deborah Watson-Jones |
| author_facet | Clare Tanton Helen A Weiss Jerome Le Goff John Changalucha Mary Rusizoka Kathy Baisley Dean Everett David A Ross Laurent Belec Richard J Hayes Deborah Watson-Jones |
| author_sort | Clare Tanton |
| collection | DOAJ |
| description | <h4>Background</h4>Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised controlled trial of HSV suppressive therapy (aciclovir 400 mg b.i.d vs. placebo) in Tanzania.<h4>Methodology</h4>Samples, including a cervico-vaginal lavage, were collected and tested for genital HIV-1 and HSV and reproductive tract infections (RTIs) at randomisation and 6, 12 and 24 months follow-up. Data from all women at randomisation and women in the placebo arm during follow-up were analysed using generalised estimating equations to determine the correlates of cervico-vaginal HIV-1 RNA detection and load.<h4>Principal findings</h4>Cervico-vaginal HIV-1 RNA was detected at 52.0% of 971 visits among 482 women, and was independently associated with plasma viral load, presence of genital ulcers, pregnancy, bloody cervical or vaginal discharge, abnormal vaginal discharge, cervical ectopy, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, an intermediate bacterial vaginosis score and HSV DNA detection. Similar factors were associated with genital HIV-1 RNA load.<h4>Conclusions</h4>RTIs were associated with increased presence and quantity of genital HIV-1 RNA in this population. These results highlight the importance of integrating effective RTI treatment into HIV care services. |
| format | Article |
| id | doaj-art-7cd1683ed57a45bc8d2daa9723b26fe8 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7cd1683ed57a45bc8d2daa9723b26fe82025-08-20T03:10:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-03-0163e1748010.1371/journal.pone.0017480Correlates of HIV-1 genital shedding in Tanzanian women.Clare TantonHelen A WeissJerome Le GoffJohn ChangaluchaMary RusizokaKathy BaisleyDean EverettDavid A RossLaurent BelecRichard J HayesDeborah Watson-Jones<h4>Background</h4>Understanding the correlates of HIV shedding is important to inform strategies to reduce HIV infectiousness. We examined correlates of genital HIV-1 RNA in women who were seropositive for both herpes simplex virus (HSV)-2 and HIV-1 and who were enrolled in a randomised controlled trial of HSV suppressive therapy (aciclovir 400 mg b.i.d vs. placebo) in Tanzania.<h4>Methodology</h4>Samples, including a cervico-vaginal lavage, were collected and tested for genital HIV-1 and HSV and reproductive tract infections (RTIs) at randomisation and 6, 12 and 24 months follow-up. Data from all women at randomisation and women in the placebo arm during follow-up were analysed using generalised estimating equations to determine the correlates of cervico-vaginal HIV-1 RNA detection and load.<h4>Principal findings</h4>Cervico-vaginal HIV-1 RNA was detected at 52.0% of 971 visits among 482 women, and was independently associated with plasma viral load, presence of genital ulcers, pregnancy, bloody cervical or vaginal discharge, abnormal vaginal discharge, cervical ectopy, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, an intermediate bacterial vaginosis score and HSV DNA detection. Similar factors were associated with genital HIV-1 RNA load.<h4>Conclusions</h4>RTIs were associated with increased presence and quantity of genital HIV-1 RNA in this population. These results highlight the importance of integrating effective RTI treatment into HIV care services.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017480&type=printable |
| spellingShingle | Clare Tanton Helen A Weiss Jerome Le Goff John Changalucha Mary Rusizoka Kathy Baisley Dean Everett David A Ross Laurent Belec Richard J Hayes Deborah Watson-Jones Correlates of HIV-1 genital shedding in Tanzanian women. PLoS ONE |
| title | Correlates of HIV-1 genital shedding in Tanzanian women. |
| title_full | Correlates of HIV-1 genital shedding in Tanzanian women. |
| title_fullStr | Correlates of HIV-1 genital shedding in Tanzanian women. |
| title_full_unstemmed | Correlates of HIV-1 genital shedding in Tanzanian women. |
| title_short | Correlates of HIV-1 genital shedding in Tanzanian women. |
| title_sort | correlates of hiv 1 genital shedding in tanzanian women |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017480&type=printable |
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