B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature
B7-H3 (CD276), a member of the B7 immune checkpoint family, plays a critical role in modulating immune responses and has emerged as a promising target in cancer therapy. It is highly expressed in various malignancies, where it promotes tumor evasion from T cell surveillance and contributes to cancer...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/14/7/530 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849730789761089536 |
|---|---|
| author | Sylwia Mielcarska Anna Kot Agnieszka Kula Miriam Dawidowicz Piotr Sobków Daria Kłaczka Dariusz Waniczek Elżbieta Świętochowska |
| author_facet | Sylwia Mielcarska Anna Kot Agnieszka Kula Miriam Dawidowicz Piotr Sobków Daria Kłaczka Dariusz Waniczek Elżbieta Świętochowska |
| author_sort | Sylwia Mielcarska |
| collection | DOAJ |
| description | B7-H3 (CD276), a member of the B7 immune checkpoint family, plays a critical role in modulating immune responses and has emerged as a promising target in cancer therapy. It is highly expressed in various malignancies, where it promotes tumor evasion from T cell surveillance and contributes to cancer progression, metastasis, and therapeutic resistance, showing a correlation with the poor prognosis of patients. Although its receptors were not fully identified, B7-H3 signaling involves key intracellular pathways, including JAK/STAT, NF-κB, PI3K/Akt, and MAPK, driving processes crucial for supporting tumor growth such as cell proliferation, invasion, and apoptosis inhibition. Beyond immune modulation, B7-H3 influences cancer cell metabolism, angiogenesis, and epithelial-to-mesenchymal transition, further exacerbating tumor aggressiveness. The development of B7-H3-targeting therapies, including monoclonal antibodies, antibody–drug conjugates, and CAR-T cells, offers promising avenues for treatment. This review provides an up-to-date summary of the B7H3 mechanisms of action, putative receptors, and ongoing clinical trials evaluating therapies targeting B7H3, focusing on the molecule’s role in gastrointestinal tumors. |
| format | Article |
| id | doaj-art-7cd091d502094a30baf9ccd2ad13fc87 |
| institution | DOAJ |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-7cd091d502094a30baf9ccd2ad13fc872025-08-20T03:08:46ZengMDPI AGCells2073-44092025-04-0114753010.3390/cells14070530B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the LiteratureSylwia Mielcarska0Anna Kot1Agnieszka Kula2Miriam Dawidowicz3Piotr Sobków4Daria Kłaczka5Dariusz Waniczek6Elżbieta Świętochowska7Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-514 Katowice, PolandDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-514 Katowice, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandDepartment of Oncological Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-514 Katowice, PolandDepartment of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandB7-H3 (CD276), a member of the B7 immune checkpoint family, plays a critical role in modulating immune responses and has emerged as a promising target in cancer therapy. It is highly expressed in various malignancies, where it promotes tumor evasion from T cell surveillance and contributes to cancer progression, metastasis, and therapeutic resistance, showing a correlation with the poor prognosis of patients. Although its receptors were not fully identified, B7-H3 signaling involves key intracellular pathways, including JAK/STAT, NF-κB, PI3K/Akt, and MAPK, driving processes crucial for supporting tumor growth such as cell proliferation, invasion, and apoptosis inhibition. Beyond immune modulation, B7-H3 influences cancer cell metabolism, angiogenesis, and epithelial-to-mesenchymal transition, further exacerbating tumor aggressiveness. The development of B7-H3-targeting therapies, including monoclonal antibodies, antibody–drug conjugates, and CAR-T cells, offers promising avenues for treatment. This review provides an up-to-date summary of the B7H3 mechanisms of action, putative receptors, and ongoing clinical trials evaluating therapies targeting B7H3, focusing on the molecule’s role in gastrointestinal tumors.https://www.mdpi.com/2073-4409/14/7/530B7H3 (CD276)immune checkpointgastrointestinal cancersimmunotherapy |
| spellingShingle | Sylwia Mielcarska Anna Kot Agnieszka Kula Miriam Dawidowicz Piotr Sobków Daria Kłaczka Dariusz Waniczek Elżbieta Świętochowska B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature Cells B7H3 (CD276) immune checkpoint gastrointestinal cancers immunotherapy |
| title | B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature |
| title_full | B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature |
| title_fullStr | B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature |
| title_full_unstemmed | B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature |
| title_short | B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature |
| title_sort | b7h3 in gastrointestinal tumors role in immune modulation and cancer progression a review of the literature |
| topic | B7H3 (CD276) immune checkpoint gastrointestinal cancers immunotherapy |
| url | https://www.mdpi.com/2073-4409/14/7/530 |
| work_keys_str_mv | AT sylwiamielcarska b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT annakot b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT agnieszkakula b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT miriamdawidowicz b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT piotrsobkow b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT dariakłaczka b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT dariuszwaniczek b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature AT elzbietaswietochowska b7h3ingastrointestinaltumorsroleinimmunemodulationandcancerprogressionareviewoftheliterature |