Anesthetic Techniques and Cancer Recurrence after Surgery
Many of the most common anesthetics are used in surgical oncology, yet effects on cancer cells are still not known. Anesthesia technique could differentially affect cancer recurrence in oncologic patients undergoing surgery, due to immunosuppression, stimulation of angiogenesis, and dissemination of...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/328513 |
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| author | Vincenzo Fodale Maria G. D’Arrigo Stefania Triolo Stefania Mondello Domenico La Torre |
| author_facet | Vincenzo Fodale Maria G. D’Arrigo Stefania Triolo Stefania Mondello Domenico La Torre |
| author_sort | Vincenzo Fodale |
| collection | DOAJ |
| description | Many of the most common anesthetics are used in surgical oncology, yet effects on cancer cells are still not known. Anesthesia technique could differentially affect cancer recurrence in oncologic patients undergoing surgery, due to immunosuppression, stimulation of angiogenesis, and dissemination of residual cancer cells. Data support the use of intravenous anesthetics, such as propofol anesthesia, thanks to antitumoral protective effects inhibiting cyclooxygenase 2 and prostaglandins E2 in cancer cells, and stimulation of immunity response; a restriction in the use of volatile anesthetics; restriction in the use of opioids as they suppress humoral and cellular immunity, and their chronic use favors angiogenesis and development of metastases; use of locoregional anesthesia compared with general anesthesia, as locoregional appears to reduce cancer recurrence after surgery. However, these findings must be interpreted cautiously as there is no evidence that simple changes in the practice of anesthesia can have a positive impact on postsurgical survival of cancer patients. |
| format | Article |
| id | doaj-art-7cc9f3f411ab4ff4aa18cb21270c4d56 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7cc9f3f411ab4ff4aa18cb21270c4d562025-08-20T02:07:25ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/328513328513Anesthetic Techniques and Cancer Recurrence after SurgeryVincenzo Fodale0Maria G. D’Arrigo1Stefania Triolo2Stefania Mondello3Domenico La Torre4Department of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico Universitario Pad. E, Piano 1, Via C. Valeria, 98125 Messina, ItalyDepartment of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico Universitario Pad. E, Piano 1, Via C. Valeria, 98125 Messina, ItalyDepartment of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico Universitario Pad. E, Piano 1, Via C. Valeria, 98125 Messina, ItalyDepartment of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico Universitario Pad. E, Piano 1, Via C. Valeria, 98125 Messina, ItalyDepartment of Neuroscience, Psychiatric and Anesthesiological Sciences, University of Messina, Policlinico Universitario Pad. E, Piano 1, Via C. Valeria, 98125 Messina, ItalyMany of the most common anesthetics are used in surgical oncology, yet effects on cancer cells are still not known. Anesthesia technique could differentially affect cancer recurrence in oncologic patients undergoing surgery, due to immunosuppression, stimulation of angiogenesis, and dissemination of residual cancer cells. Data support the use of intravenous anesthetics, such as propofol anesthesia, thanks to antitumoral protective effects inhibiting cyclooxygenase 2 and prostaglandins E2 in cancer cells, and stimulation of immunity response; a restriction in the use of volatile anesthetics; restriction in the use of opioids as they suppress humoral and cellular immunity, and their chronic use favors angiogenesis and development of metastases; use of locoregional anesthesia compared with general anesthesia, as locoregional appears to reduce cancer recurrence after surgery. However, these findings must be interpreted cautiously as there is no evidence that simple changes in the practice of anesthesia can have a positive impact on postsurgical survival of cancer patients.http://dx.doi.org/10.1155/2014/328513 |
| spellingShingle | Vincenzo Fodale Maria G. D’Arrigo Stefania Triolo Stefania Mondello Domenico La Torre Anesthetic Techniques and Cancer Recurrence after Surgery The Scientific World Journal |
| title | Anesthetic Techniques and Cancer Recurrence after Surgery |
| title_full | Anesthetic Techniques and Cancer Recurrence after Surgery |
| title_fullStr | Anesthetic Techniques and Cancer Recurrence after Surgery |
| title_full_unstemmed | Anesthetic Techniques and Cancer Recurrence after Surgery |
| title_short | Anesthetic Techniques and Cancer Recurrence after Surgery |
| title_sort | anesthetic techniques and cancer recurrence after surgery |
| url | http://dx.doi.org/10.1155/2014/328513 |
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