Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method
At present a great attention is paid to the novel physicochemical methods of drugs analysis, notably high-performance liquid chromatography. Our investigation resulted in the development of simultaneous detection of Isoniazid and Thiotriazolin content in artificial mixture by high-performance liquid...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2014-04-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/25524/23001 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850219303059587072 |
|---|---|
| author | L. I. Kucherenko O. V. Khromylyova Z. B. Moryak H. I. Tkachenko |
| author_facet | L. I. Kucherenko O. V. Khromylyova Z. B. Moryak H. I. Tkachenko |
| author_sort | L. I. Kucherenko |
| collection | DOAJ |
| description | At present a great attention is paid to the novel physicochemical methods of drugs analysis, notably high-performance liquid chromatography. Our investigation resulted in the development of simultaneous detection of Isoniazid and Thiotriazolin content in artificial mixture by high-performance liquid chromatography method, notably choice of mobile and immobile phase. It is not easy because both components have different acid-base nature: Thiotriazolin has acid character and Isoniazid is rather strong base. Besides, during our research we chose optimal conditions of analysis: column, eluent, rate of mobile phase, analytical wavelength of detector and volume of input probe. Received chromatograms satisfy all requirements of standards and will be used for the development of standardization methods for «IT» tablets. |
| format | Article |
| id | doaj-art-7cc83d659cbf4dd3a679a7d5aa130055 |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2014-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-7cc83d659cbf4dd3a679a7d5aa1300552025-08-20T02:07:25ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-04-01211812010.14739/2310-1210.2014.2.25524Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography methodL. I. KucherenkoO. V. KhromylyovaZ. B. MoryakH. I. TkachenkoAt present a great attention is paid to the novel physicochemical methods of drugs analysis, notably high-performance liquid chromatography. Our investigation resulted in the development of simultaneous detection of Isoniazid and Thiotriazolin content in artificial mixture by high-performance liquid chromatography method, notably choice of mobile and immobile phase. It is not easy because both components have different acid-base nature: Thiotriazolin has acid character and Isoniazid is rather strong base. Besides, during our research we chose optimal conditions of analysis: column, eluent, rate of mobile phase, analytical wavelength of detector and volume of input probe. Received chromatograms satisfy all requirements of standards and will be used for the development of standardization methods for «IT» tablets.http://zmj.zsmu.edu.ua/article/view/25524/23001ThiotriazolinIsoniazidmixturechromatography |
| spellingShingle | L. I. Kucherenko O. V. Khromylyova Z. B. Moryak H. I. Tkachenko Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method Zaporožskij Medicinskij Žurnal Thiotriazolin Isoniazid mixture chromatography |
| title | Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method |
| title_full | Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method |
| title_fullStr | Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method |
| title_full_unstemmed | Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method |
| title_short | Choice of optimal conditions of Isoniazid and Thiotriazolin artificial mixture analysis by high-performance liquid chromatography method |
| title_sort | choice of optimal conditions of isoniazid and thiotriazolin artificial mixture analysis by high performance liquid chromatography method |
| topic | Thiotriazolin Isoniazid mixture chromatography |
| url | http://zmj.zsmu.edu.ua/article/view/25524/23001 |
| work_keys_str_mv | AT likucherenko choiceofoptimalconditionsofisoniazidandthiotriazolinartificialmixtureanalysisbyhighperformanceliquidchromatographymethod AT ovkhromylyova choiceofoptimalconditionsofisoniazidandthiotriazolinartificialmixtureanalysisbyhighperformanceliquidchromatographymethod AT zbmoryak choiceofoptimalconditionsofisoniazidandthiotriazolinartificialmixtureanalysisbyhighperformanceliquidchromatographymethod AT hitkachenko choiceofoptimalconditionsofisoniazidandthiotriazolinartificialmixtureanalysisbyhighperformanceliquidchromatographymethod |