Manifestation of plasmablastic lymphoma in the oral cavity: Report of two cases and literature review

Manifestation of plasmablastic lymphoma in the oral cavity: Report of two cases and literature review

Plasmablastic lymphoma (PBL) is a rare and aggressive non- Hodgkin 's B-cell lymphoma initially reported in patients with the HIV virus with a predilection for the oral cavity. It can affect individuals with other types of immunodeficiency and appear in extra-oral sites, also demonstrating an a...

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Main Authors: Letícia da Silva Soares Gomes, Caroline Alfaia Silva, André Luiz Carvalho Barreiros, Patrick Rocha Osborne, Jeconias Câmara, Tiago Novaes Pinheiro, Christina Shiang, José Augusto Andrade Godoy Bezerra, Naíza Menezes Medeiros Abrahim, Luciana Botinelly Mendonça Fujimoto
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Oral Oncology Reports
Subjects:
Plasmablastic lymphoma
Non-hodgkin lymphoma
HIV
Oral cavity
EBV
Online Access:http://www.sciencedirect.com/science/article/pii/S2772906024000049
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Summary:Plasmablastic lymphoma (PBL) is a rare and aggressive non- Hodgkin 's B-cell lymphoma initially reported in patients with the HIV virus with a predilection for the oral cavity. It can affect individuals with other types of immunodeficiency and appear in extra-oral sites, also demonstrating an association with Epstein-Barr Virus (EBV) infection. Histopathological diagnosis is challenging due to overlapping features of other high-grade lymphomas and plasma cell lesions. The objective of the study was to report two cases of oral manifestations of Plasmablastic Lymphoma, in a patient with different HIV serological status and EBV positivity, aiming to present and discuss information regarding the clinical presentation, laboratory and immunohistochemical findings, proposed treatment and a review of updated literature on the topic.
ISSN:2772-9060

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