Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema
Abstract Significance of this study Reduced pulse pressure (PP) reflects impaired systemic perfusion and may exacerbate retinal ischemia in central retinal vein occlusion-induced macular edema (CRVO-ME) by compromising ocular blood flow autoregulation. This hemodynamic dysfunction is hypothesized to...
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02884-x |
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| author | Yu Song Qian Wang Yu Du Hong Tian Yangyang Xu Rui Min Chen Shancheng Si |
| author_facet | Yu Song Qian Wang Yu Du Hong Tian Yangyang Xu Rui Min Chen Shancheng Si |
| author_sort | Yu Song |
| collection | DOAJ |
| description | Abstract Significance of this study Reduced pulse pressure (PP) reflects impaired systemic perfusion and may exacerbate retinal ischemia in central retinal vein occlusion-induced macular edema (CRVO-ME) by compromising ocular blood flow autoregulation. This hemodynamic dysfunction is hypothesized to worsen clinical outcomes and neovascular risks. Purposes To investigate the associations between potential prognostic biomarkers and clinical outcomes in treatment-naïve CRVO-ME and assess their predictive utilities. Methods In this retrospective cohort study conducted from March 2019 to March 2024, we analyzed 101 treatment-naïve CRVO-ME patients stratified by outcomes: favorable (endpoint best-corrected visual acuity [BCVA] ≥ 20/100 without CRVO-induced neovascular glaucoma [CRVO-NVG]) versus unfavorable (endpoint BCVA < 20/100 or CRVO-NVG development). We compared demographic characteristics, baseline blood pressures, ocular features, and systemic biomarkers between groups. Results Multivariable logistic regression analysis identified two independent predictors of unfavorable outcomes: suboptimal 1-month post-injection BCVA (odds ratio [OR] = 1.824 per 0.1 log MAR unit increase, 95% confidence intervals [CI] 1.236–2.691, P = 0.002) and diminished PP (OR = 1.147 per mmHg decrease, 95% CI 1.028–1.279, P = 0.015). Receiver operating characteristic analysis demonstrated strong predictive accuracy for both parameters (1-month post-injection BCVA: area under the receiver operating characteristic curve [AUROC] = 0.843, cutoff 0.85 logarithm of the minimum angle of resolution [log MAR], P = 0.000; PP: AUROC = 0.812, cutoff 57 mmHg, P = 0.000). In the ischemic CRVO-ME subgroup (n = 27), the optical coherence tomography (OCT)-defined “over-response to the first intravitreal injection (ORIVI)” emerged as the sole significant predictor of CRVO-NVG development (OR = 15.167, 95% CI 1.509–152.464, P = 0.026). Conclusion This study establishes baseline PP < 57 mmHg and suboptimal 1-month post-injection BCVA > 0.85 log MAR as key prognostic indicators in CRVO-ME, while identifying the ORIVI sign as a specific predictor of CRVO-NVG in ischemic cases. These findings introduce easily obtainable systemic parameter (PP) for risk assessment, define 1-month visual response as key treatment evaluation point, propose ORIVI sign as an imaging biomarker for ischemic CRVO complications. |
| format | Article |
| id | doaj-art-7cc33dce970842d88fa62c17d64afa4d |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj-art-7cc33dce970842d88fa62c17d64afa4d2025-08-20T03:42:20ZengBMCEuropean Journal of Medical Research2047-783X2025-07-0130111110.1186/s40001-025-02884-xPrognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edemaYu Song0Qian Wang1Yu Du2Hong Tian3Yangyang Xu4Rui Min Chen5Shancheng Si6Department of Ophthalmology, Weihai Central Hospital Affiliated to Qingdao UniversityDepartment of Ophthalmology, Weihai Central Hospital Affiliated to Qingdao UniversityTsinghua Medicine, Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua UniversityDepartment of Cataract, Baotou Kunlun Chaoju Eye HospitalTsinghua Medicine, Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua UniversityTsinghua Medicine, Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua UniversityTsinghua Medicine, Beijing Tsinghua Changgung Hospital Eye Center, Beijing Visual Science and Translational Eye Research Institute (BERI), Tsinghua UniversityAbstract Significance of this study Reduced pulse pressure (PP) reflects impaired systemic perfusion and may exacerbate retinal ischemia in central retinal vein occlusion-induced macular edema (CRVO-ME) by compromising ocular blood flow autoregulation. This hemodynamic dysfunction is hypothesized to worsen clinical outcomes and neovascular risks. Purposes To investigate the associations between potential prognostic biomarkers and clinical outcomes in treatment-naïve CRVO-ME and assess their predictive utilities. Methods In this retrospective cohort study conducted from March 2019 to March 2024, we analyzed 101 treatment-naïve CRVO-ME patients stratified by outcomes: favorable (endpoint best-corrected visual acuity [BCVA] ≥ 20/100 without CRVO-induced neovascular glaucoma [CRVO-NVG]) versus unfavorable (endpoint BCVA < 20/100 or CRVO-NVG development). We compared demographic characteristics, baseline blood pressures, ocular features, and systemic biomarkers between groups. Results Multivariable logistic regression analysis identified two independent predictors of unfavorable outcomes: suboptimal 1-month post-injection BCVA (odds ratio [OR] = 1.824 per 0.1 log MAR unit increase, 95% confidence intervals [CI] 1.236–2.691, P = 0.002) and diminished PP (OR = 1.147 per mmHg decrease, 95% CI 1.028–1.279, P = 0.015). Receiver operating characteristic analysis demonstrated strong predictive accuracy for both parameters (1-month post-injection BCVA: area under the receiver operating characteristic curve [AUROC] = 0.843, cutoff 0.85 logarithm of the minimum angle of resolution [log MAR], P = 0.000; PP: AUROC = 0.812, cutoff 57 mmHg, P = 0.000). In the ischemic CRVO-ME subgroup (n = 27), the optical coherence tomography (OCT)-defined “over-response to the first intravitreal injection (ORIVI)” emerged as the sole significant predictor of CRVO-NVG development (OR = 15.167, 95% CI 1.509–152.464, P = 0.026). Conclusion This study establishes baseline PP < 57 mmHg and suboptimal 1-month post-injection BCVA > 0.85 log MAR as key prognostic indicators in CRVO-ME, while identifying the ORIVI sign as a specific predictor of CRVO-NVG in ischemic cases. These findings introduce easily obtainable systemic parameter (PP) for risk assessment, define 1-month visual response as key treatment evaluation point, propose ORIVI sign as an imaging biomarker for ischemic CRVO complications.https://doi.org/10.1186/s40001-025-02884-xCentral retinal vein occlusion-induced macular edemaNeovascular glaucomaUnfavorable outcomesPulse pressureNon-invasive acquired risk factors |
| spellingShingle | Yu Song Qian Wang Yu Du Hong Tian Yangyang Xu Rui Min Chen Shancheng Si Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema European Journal of Medical Research Central retinal vein occlusion-induced macular edema Neovascular glaucoma Unfavorable outcomes Pulse pressure Non-invasive acquired risk factors |
| title | Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema |
| title_full | Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema |
| title_fullStr | Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema |
| title_full_unstemmed | Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema |
| title_short | Prognostic biomarkers in treatment-naïve central retinal vein occlusion with macular edema |
| title_sort | prognostic biomarkers in treatment naive central retinal vein occlusion with macular edema |
| topic | Central retinal vein occlusion-induced macular edema Neovascular glaucoma Unfavorable outcomes Pulse pressure Non-invasive acquired risk factors |
| url | https://doi.org/10.1186/s40001-025-02884-x |
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