Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.
Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145507&type=printable |
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| author | Yuan Lu Nicholas Starkey Wei Lei Jilong Li Jianlin Cheng William R Folk Dennis B Lubahn |
| author_facet | Yuan Lu Nicholas Starkey Wei Lei Jilong Li Jianlin Cheng William R Folk Dennis B Lubahn |
| author_sort | Yuan Lu |
| collection | DOAJ |
| description | Sutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk. |
| format | Article |
| id | doaj-art-7cc2ddd10535413e9d49c37f4928fabb |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-7cc2ddd10535413e9d49c37f4928fabb2025-08-20T03:11:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014550710.1371/journal.pone.0145507Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.Yuan LuNicholas StarkeyWei LeiJilong LiJianlin ChengWilliam R FolkDennis B LubahnSutherlandia frutescens (L) R. Br. (Sutherlandia) is a South African botanical that is traditionally used to treat a variety of health conditions, infections and diseases, including cancer. We hypothesized Sutherlandia might act through Gli/ Hedgehog (Hh)-signaling in prostate cancer cells and used RNA-Seq transcription profiling to profile gene expression in TRAMPC2 murine prostate cancer cells with or without Sutherlandia extracts. We found 50% of Hh-responsive genes can be repressed by Sutherlandia ethanol extract, including the canonical Hh-responsive genes Gli1 and Ptch1 as well as newly distinguished Hh-responsive genes Hsd11b1 and Penk.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145507&type=printable |
| spellingShingle | Yuan Lu Nicholas Starkey Wei Lei Jilong Li Jianlin Cheng William R Folk Dennis B Lubahn Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. PLoS ONE |
| title | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. |
| title_full | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. |
| title_fullStr | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. |
| title_full_unstemmed | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. |
| title_short | Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract. |
| title_sort | inhibition of hedgehog signaling driven genes in prostate cancer cells by sutherlandia frutescens extract |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145507&type=printable |
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