Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor–Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor–p65–Signal Transducer and Activator of Transcription 3 Complex

Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor–Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor–p65–Signal Transducer and Activator of Transcription 3 Complex

Background Mineralocorticoid receptor (MR) induces cardiac inflammation cooperatively with nuclear factor‐κB and signal transducer and activator of transcription 3 (STAT3); MR blockers exert anti‐inflammatory effects. However, the underlying mechanism remains unclear. We investigated the anti‐inflam...

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Bibliographic Details
Main Authors: Naoto Kuyama, Satoshi Araki, Koichi Kaikita, Nobuhiro Nakanishi, Naoya Nakashima, Shinsuke Hanatani, Yuichiro Arima, Masahiro Yamamoto, Taishi Nakamura, Eiichiro Yamamoto, Kenichi Matsushita, Kunihiko Matsui, Kenichi Tsujita
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
esaxerenone
interleukin‐6
mineralocorticoid receptor
myocardial infarction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.030941
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