HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana
Abstract HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. Al...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | AIDS Research and Therapy |
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| Online Access: | https://doi.org/10.1186/s12981-025-00762-4 |
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| author | Adwoa K.A Afrane Vlad Novitsky Joel Hague Kwamena Sagoe Yakubu Alhassan Joycelyn Assimeng Dame Charles Martyn-Dickens Margaret Lartey Bamenla Goka Kwasi Torpey Rami Kantor Awewura Kwara |
| author_facet | Adwoa K.A Afrane Vlad Novitsky Joel Hague Kwamena Sagoe Yakubu Alhassan Joycelyn Assimeng Dame Charles Martyn-Dickens Margaret Lartey Bamenla Goka Kwasi Torpey Rami Kantor Awewura Kwara |
| author_sort | Adwoa K.A Afrane |
| collection | DOAJ |
| description | Abstract HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed. |
| format | Article |
| id | doaj-art-7cbedc4602204ac485aea84863824728 |
| institution | DOAJ |
| issn | 1742-6405 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj-art-7cbedc4602204ac485aea848638247282025-08-20T03:06:06ZengBMCAIDS Research and Therapy1742-64052025-07-012211610.1186/s12981-025-00762-4HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in GhanaAdwoa K.A Afrane0Vlad Novitsky1Joel Hague2Kwamena Sagoe3Yakubu Alhassan4Joycelyn Assimeng Dame5Charles Martyn-Dickens6Margaret Lartey7Bamenla Goka8Kwasi Torpey9Rami Kantor10Awewura Kwara11Department of Child Health, University of Ghana Medical School and Korle- Bu Teaching HospitalDivision of Infectious Diseases, Brown University Alpert Medical SchoolDivision of Infectious Diseases, Brown University Alpert Medical SchoolDepartment of Medical Microbiology, University of Ghana Medical SchoolDepartment of Biostatistics, School of Public Health, University of GhanaDepartment of Child Health, University of Ghana Medical School and Korle- Bu Teaching HospitalDirectorate of Child Health, Komfo Anokye Teaching HospitalDepartment of Medicine and Therapeutics, University of Ghana Medical School and Korle-Bu Teaching HospitalDepartment of Child Health, University of Ghana Medical School and Korle- Bu Teaching HospitalDepartment of Population, Family and Reproductive Health, School of Public Health, University of GhanaDivision of Infectious Diseases, Brown University Alpert Medical SchoolDivision of Infectious Diseases and Global Medicine, University of Florida College of MedicineAbstract HIV drug resistance (HIVDR) was retrospectively characterized among 20 children and adolescents with HIV with virologic failure on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based therapy, and virologic response in those switched to dolutegravir (DTG)-based therapy described. All participants had at least one NNRTI resistance mutation, most commonly K103N (N = 12) and 15 (75%) had nucleoside reverse transcriptase inhibitor (NRTI) resistance mutations, most commonly M184I/V (N = 15). Five (45%) of 11 participants who were switched to DTG-based regimens for a median of 50 months had HIV suppression. Further studies to understand the role of pre-existing HIVDR in the failure of DTG-based regimens are needed.https://doi.org/10.1186/s12981-025-00762-4NNRTIsHIV drug resistanceChildren and adolescentsDolutegravirAntiretroviral therapyGhana |
| spellingShingle | Adwoa K.A Afrane Vlad Novitsky Joel Hague Kwamena Sagoe Yakubu Alhassan Joycelyn Assimeng Dame Charles Martyn-Dickens Margaret Lartey Bamenla Goka Kwasi Torpey Rami Kantor Awewura Kwara HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana AIDS Research and Therapy NNRTIs HIV drug resistance Children and adolescents Dolutegravir Antiretroviral therapy Ghana |
| title | HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana |
| title_full | HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana |
| title_fullStr | HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana |
| title_full_unstemmed | HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana |
| title_short | HIV drug resistance in children and adolescents on NNRTI-based antiretroviral therapy and subsequent virologic response to dolutegravir-based regimens in Ghana |
| title_sort | hiv drug resistance in children and adolescents on nnrti based antiretroviral therapy and subsequent virologic response to dolutegravir based regimens in ghana |
| topic | NNRTIs HIV drug resistance Children and adolescents Dolutegravir Antiretroviral therapy Ghana |
| url | https://doi.org/10.1186/s12981-025-00762-4 |
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