Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report
Salivary Duct Carcinoma (SDC) is a rare and highly aggressive cancer that originates in the ductal epithelium of the salivary glands, primarily affecting the parotid and submandibular glands. Cases involving minor salivary glands are uncommon. Due to its high grade, SDC requires aggressive treatment...
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JCDR Research and Publications Private Limited
2025-05-01
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| author | Srishti Manoj Balwant Gaurav Datta Devyani Mohanlal Bathani Ashray Jain Tapan Nagpal |
| author_facet | Srishti Manoj Balwant Gaurav Datta Devyani Mohanlal Bathani Ashray Jain Tapan Nagpal |
| author_sort | Srishti Manoj Balwant |
| collection | DOAJ |
| description | Salivary Duct Carcinoma (SDC) is a rare and highly aggressive cancer that originates in the ductal epithelium of the salivary glands, primarily affecting the parotid and submandibular glands. Cases involving minor salivary glands are uncommon. Due to its high grade, SDC requires aggressive treatment, including complete local excision and postoperative radiotherapy for optimal patient outcomes. The present report discusses a case involving a 50-year-old male with a solitary, firm, non tender swelling measuring approximately 4×4 cm in the right submandibular region, extending to the tonsillolingual junction. The right floor of the mouth displayed a fixed, congested mucosa attached to a palpable mass, causing oral bleeding. Histopathology revealed a cribriform pattern with comedo necrosis. Immunohistochemistry confirmed the diagnosis of SDC, with tumour cells showing positive results for cytokeratin-7, c-erb B2 and Mindbomb Homolog-1 (MIB-1). The mass was surgically excised, followed by postoperative radiotherapy. The patient was monitored for 21 months without any local recurrence or distant metastasis, indicating successful treatment. Complete surgical excision of the swelling, followed by postoperative radiotherapy, can lead to disease-free survival with early diagnosis and proper management. |
| format | Article |
| id | doaj-art-7cbe733ec5364a138db522da778b76de |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-7cbe733ec5364a138db522da778b76de2025-08-20T03:47:36ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-05-01195MD10MD1310.7860/JCDR/2025/78981.21022Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case ReportSrishti Manoj Balwant0Gaurav Datta1Devyani Mohanlal Bathani2Ashray Jain3Tapan Nagpal43rd Year Resident, Department of Otorhinolaryngology, SBKS MI&RC, Vadodara, Gujarat, India.Assistant Professor, Department of Otorhinolaryngology, SBKS MI&RC, Vadodara, Gujarat, India.3rd Year Resident, Department of Otorhinolaryngology, SBKS MI&RC, Vadodara, Gujarat, India.3rd Year Resident, Department of Otorhinolaryngology, SBKS MI&RC, Vadodara, Gujarat, India.Professor and Head, Department of Otorhinolaryngology, SBKS MI&RC, Vadodara, Gujarat, India.Salivary Duct Carcinoma (SDC) is a rare and highly aggressive cancer that originates in the ductal epithelium of the salivary glands, primarily affecting the parotid and submandibular glands. Cases involving minor salivary glands are uncommon. Due to its high grade, SDC requires aggressive treatment, including complete local excision and postoperative radiotherapy for optimal patient outcomes. The present report discusses a case involving a 50-year-old male with a solitary, firm, non tender swelling measuring approximately 4×4 cm in the right submandibular region, extending to the tonsillolingual junction. The right floor of the mouth displayed a fixed, congested mucosa attached to a palpable mass, causing oral bleeding. Histopathology revealed a cribriform pattern with comedo necrosis. Immunohistochemistry confirmed the diagnosis of SDC, with tumour cells showing positive results for cytokeratin-7, c-erb B2 and Mindbomb Homolog-1 (MIB-1). The mass was surgically excised, followed by postoperative radiotherapy. The patient was monitored for 21 months without any local recurrence or distant metastasis, indicating successful treatment. Complete surgical excision of the swelling, followed by postoperative radiotherapy, can lead to disease-free survival with early diagnosis and proper management.https://jcdr.net/articles/PDF/21022/78981_CE[Ra1]_F(IS)_QC(PS_SS)_PF1(RI_SS)_PFA(IS)_PN(IS).pdfimmunohistochemistrylymph nodesradiotherapy |
| spellingShingle | Srishti Manoj Balwant Gaurav Datta Devyani Mohanlal Bathani Ashray Jain Tapan Nagpal Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report Journal of Clinical and Diagnostic Research immunohistochemistry lymph nodes radiotherapy |
| title | Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report |
| title_full | Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report |
| title_fullStr | Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report |
| title_full_unstemmed | Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report |
| title_short | Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report |
| title_sort | salivary duct carcinoma with comedo necrosis in level 1b lymph nodes a case report |
| topic | immunohistochemistry lymph nodes radiotherapy |
| url | https://jcdr.net/articles/PDF/21022/78981_CE[Ra1]_F(IS)_QC(PS_SS)_PF1(RI_SS)_PFA(IS)_PN(IS).pdf |
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