Salivary Duct Carcinoma with Comedo Necrosis in Level 1B Lymph Nodes: A Case Report
Salivary Duct Carcinoma (SDC) is a rare and highly aggressive cancer that originates in the ductal epithelium of the salivary glands, primarily affecting the parotid and submandibular glands. Cases involving minor salivary glands are uncommon. Due to its high grade, SDC requires aggressive treatment...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/21022/78981_CE[Ra1]_F(IS)_QC(PS_SS)_PF1(RI_SS)_PFA(IS)_PN(IS).pdf |
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| Summary: | Salivary Duct Carcinoma (SDC) is a rare and highly aggressive cancer that originates in the ductal epithelium of the salivary glands, primarily affecting the parotid and submandibular glands. Cases involving minor salivary glands are uncommon. Due to its high grade, SDC requires aggressive treatment, including complete local excision and postoperative radiotherapy for optimal patient outcomes. The present report discusses a case involving a 50-year-old male with a solitary, firm, non tender swelling measuring approximately 4×4 cm in the right submandibular region, extending to the tonsillolingual junction. The right floor of the mouth displayed a fixed, congested mucosa attached to a palpable mass, causing oral bleeding. Histopathology revealed a cribriform pattern with comedo necrosis. Immunohistochemistry confirmed the diagnosis of SDC, with tumour cells showing positive results for cytokeratin-7, c-erb B2 and Mindbomb Homolog-1 (MIB-1). The mass was surgically excised, followed by postoperative radiotherapy. The patient was monitored for 21 months without any local recurrence or distant metastasis, indicating successful treatment. Complete surgical excision of the swelling, followed by postoperative radiotherapy, can lead to disease-free survival with early diagnosis and proper management. |
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| ISSN: | 2249-782X 0973-709X |